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Product Details
PA5-114672
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human WEE1(Accession P30291), corresponding to amino acid residues around phosphorylated Ser642.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2899308
Product Specific Information
Antibody detects endogenous levels of WEE1 only when phosphorylated at Ser642.
Target Information
WEE1, which is classified as a Ser/Thr kinase by sequence analysis, has been shown to inactivate multiple CDKs by tyrosine phosphorylation. Wee1 protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686I18166; FLJ16446; wee 1 homolog; WEE1 homolog; WEE1 tyrosine kinase; WEE1+ homolog; Wee1-like protein kinase; Wee1A kinase; WEE1hu
Gene Aliases: WEE1; WEE1A; WEE1hu
UniProt ID: (Human) P30291, (Mouse) P47810, (Rat) Q63802
Entrez Gene ID: (Human) 7465, (Mouse) 22390, (Rat) 308937
magnesium ion binding
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
nucleotide binding
protein kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
protein serine/threonine kinase activity
non-receptor serine/threonine protein kinase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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