Proteintech

RAB1A Polyclonal Antibody

RAB1A Antibody in Immunocytochemistry (ICC/IF)

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RAB1A Antibody (11671-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA) fixed NIH/3T3 cells using 11671-1-AP (RAB1A antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

RAB1A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

11671-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 5 publications 5 publications

Immunoprecipitation (IP)

Assay-dependent

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RAB1A Fusion Protein Ag2264 (1-205 aa encoded by BC000905)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSSMNPEYD YLFKLLLIGD SGVGKSCLLL RFADDTYTES YISTIGVDFK IRTIELDGKT IKLQIWDTAG QERFRTITSS YYRGAHGIIV VYDVTDQESF NNVKQWLQEI DRYASENVNK LLVGNKCDLT TKKVVDYTTA KEFADSLGIP FLETSAKNAT NVEQSFMTMA AEIKKRMGPG ATAGGAEKSN VKIQSTPVKQ SGGGCC (1-205 aa encoded by B C000905)

Target Information

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence.

Life science alliance

Gyurkovska V,Murtazina R,Zhao SF,Shikano S,Okamoto Y,Segev N

Mon May 01 00:00:00 EDT 2023

Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction.

Frontiers in pharmacology

Deng D,Qu Y,Sun L,Jia L,Bu J,Ye M,Chen Z,Geng Y,Zhou S,Fang B

Wed Mar 10 00:00:00 EST 2021

Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.

Scientific reports

Peng C,Li X,Ye Z,Wu W

Tue Aug 10 00:00:00 EDT 2021

Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.

Cell reports

Zhang X,Wang X,Yuan Z,Radford SJ,Liu C,Libutti SK,Zheng XFS

Tue Mar 16 00:00:00 EDT 2021

Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.

Cell reports

Zhang X,Wang X,Yuan Z,Radford SJ,Liu C,Libutti SK,Zheng XFS

Tue Mar 16 00:00:00 EDT 2021

Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer.

Cancer letters

Huang T,Chen B,Wang F,Cai W,Wang X,Huang B,Liu F,Jiang B,Zhang Y

Tue Dec 28 00:00:00 EST 2021

Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer.

Cancer letters

Huang T,Chen B,Wang F,Cai W,Wang X,Huang B,Liu F,Jiang B,Zhang Y

Tue Dec 28 00:00:00 EST 2021

Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer.

Cancer letters

Huang T,Chen B,Wang F,Cai W,Wang X,Huang B,Liu F,Jiang B,Zhang Y

Tue Dec 28 00:00:00 EST 2021

RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial-mesenchymal transition.

Future oncology (London, England)

Ren B,Wang L,Nan Y,Liu T,Zhao L,Ma H,Li J,Zhang Y,Ren X

Sun Aug 01 00:00:00 EDT 2021

RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial-mesenchymal transition.

Future oncology (London, England)

Ren B,Wang L,Nan Y,Liu T,Zhao L,Ma H,Li J,Zhang Y,Ren X

Sun Aug 01 00:00:00 EDT 2021

CircRNA circ-0038718 promotes hepatocellular carcinoma progression through sponging miR-139-3p.

Biochemical and biophysical research communications

Sun R,Li H,Li J,Shen S,Cui G,Dong G

Thu Dec 17 00:00:00 EST 2020

RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells.

Autophagy

Ding X,Jiang X,Tian R,Zhao P,Li L,Wang X,Chen S,Zhu Y,Mei M,Bao S,Liu W,Tang Z,Sun Q

Tue Oct 01 00:00:00 EDT 2019

RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells.

Autophagy

Ding X,Jiang X,Tian R,Zhao P,Li L,Wang X,Chen S,Zhu Y,Mei M,Bao S,Liu W,Tang Z,Sun Q

Tue Oct 01 00:00:00 EDT 2019

RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells.

Autophagy

Ding X,Jiang X,Tian R,Zhao P,Li L,Wang X,Chen S,Zhu Y,Mei M,Bao S,Liu W,Tang Z,Sun Q

Tue Oct 01 00:00:00 EDT 2019

Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer.

Oncology reports

Cheng Z,Shao X,Xu M,Wang J,Kuai X,Zhang L,Wu J,Zhou C,Mao J

Wed May 01 00:00:00 EDT 2019

Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.

Oncology reports

Xu H,Qian M,Zhao B,Wu C,Maskey N,Song H,Li D,Song J,Hua K,Fang L

Wed Mar 01 00:00:00 EST 2017

Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.

Oncology reports

Xu H,Qian M,Zhao B,Wu C,Maskey N,Song H,Li D,Song J,Hua K,Fang L

Wed Mar 01 00:00:00 EST 2017

Tissue-based quantitative proteome analysis of human hepatocellular carcinoma using tandem mass tags.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Megger DA,Rosowski K,Ahrens M,Bracht T,Eisenacher M,Schlaak JF,Weber F,Hoffmann AC,Meyer HE,Baba HA,Sitek B

Wed Mar 01 00:00:00 EST 2017

Tissue-based quantitative proteome analysis of human hepatocellular carcinoma using tandem mass tags.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Megger DA,Rosowski K,Ahrens M,Bracht T,Eisenacher M,Schlaak JF,Weber F,Hoffmann AC,Meyer HE,Baba HA,Sitek B

Wed Mar 01 00:00:00 EST 2017

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.

The EMBO journal

Sellier C,Campanari ML,Julie Corbier C,Gaucherot A,Kolb-Cheynel I,Oulad-Abdelghani M,Ruffenach F,Page A,Ciura S,Kabashi E,Charlet-Berguerand N

Wed Jun 15 00:00:00 EDT 2016

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.

The EMBO journal

Sellier C,Campanari ML,Julie Corbier C,Gaucherot A,Kolb-Cheynel I,Oulad-Abdelghani M,Ruffenach F,Page A,Ciura S,Kabashi E,Charlet-Berguerand N

Wed Jun 15 00:00:00 EDT 2016

Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.

Human molecular genetics

Gautam M,Jara JH,Sekerkova G,Yasvoina MV,Martina M,Özdinler PH

Tue Mar 15 00:00:00 EDT 2016

Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.

Human molecular genetics

Gautam M,Jara JH,Sekerkova G,Yasvoina MV,Martina M,Özdinler PH

Tue Mar 15 00:00:00 EDT 2016

Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.

Aging

Wang X,Liu F,Qin X,Huang T,Huang B,Zhang Y,Jiang B

Tue Nov 29 00:00:00 EST 2016

Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.

Aging

Wang X,Liu F,Qin X,Huang T,Huang B,Zhang Y,Jiang B

Tue Nov 29 00:00:00 EST 2016

Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.

Aging

Wang X,Liu F,Qin X,Huang T,Huang B,Zhang Y,Jiang B

Tue Nov 29 00:00:00 EST 2016

Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.

Aging

Wang X,Liu F,Qin X,Huang T,Huang B,Zhang Y,Jiang B

Tue Nov 29 00:00:00 EST 2016

Rab1A is an mTORC1 activator and a colorectal oncogene.

Cancer cell

Thomas JD,Zhang YJ,Wei YH,Cho JH,Morris LE,Wang HY,Zheng XF

Mon Nov 10 00:00:00 EST 2014

Rab1A is an mTORC1 activator and a colorectal oncogene.

Cancer cell

Thomas JD,Zhang YJ,Wei YH,Cho JH,Morris LE,Wang HY,Zheng XF

Mon Nov 10 00:00:00 EST 2014

Rab1A is an mTORC1 activator and a colorectal oncogene.

Cancer cell

Thomas JD,Zhang YJ,Wei YH,Cho JH,Morris LE,Wang HY,Zheng XF

Mon Nov 10 00:00:00 EST 2014

Rab1A is an mTORC1 activator and a colorectal oncogene.

Cancer cell

Thomas JD,Zhang YJ,Wei YH,Cho JH,Morris LE,Wang HY,Zheng XF

Mon Nov 10 00:00:00 EST 2014

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.

Human molecular genetics

Smith GA,Rocha EM,McLean JR,Hayes MA,Izen SC,Isacson O,Hallett PJ

Mon Sep 01 00:00:00 EDT 2014

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.

Human molecular genetics

Smith GA,Rocha EM,McLean JR,Hayes MA,Izen SC,Isacson O,Hallett PJ

Mon Sep 01 00:00:00 EDT 2014

Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome.

Molecular & cellular proteomics : MCP

Campbell-Valois FX,Trost M,Chemali M,Dill BD,Laplante A,Duclos S,Sadeghi S,Rondeau C,Morrow IC,Bell C,Gagnon E,Hatsuzawa K,Thibault P,Desjardins M

Sun Jul 01 00:00:00 EDT 2012

Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome.

Molecular & cellular proteomics : MCP

Campbell-Valois FX,Trost M,Chemali M,Dill BD,Laplante A,Duclos S,Sadeghi S,Rondeau C,Morrow IC,Bell C,Gagnon E,Hatsuzawa K,Thibault P,Desjardins M

Sun Jul 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: DKFZP564B163; GTP binding protein Rab1a; Rab GTPase YPT1 homolog; RAB1, member RAS oncogene family; Ras-related protein Rab-1A; ras-related YPT1 protein; YPT1-related protein

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Gene Aliases: Ac2-048; Gtbp; mKIAA3012; Rab-1; RAB1; RAB1A; Rab1r; YPT1

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UniProt ID: (Human) P62820, (Mouse) P62821, (Rat) Q6NYB7

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Entrez Gene ID: (Human) 5861, (Mouse) 19324, (Rat) 81754

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Function(s)

GTPase activity protein binding GTP binding cadherin binding involved in cell-cell adhesion nucleotide binding GDP binding

Process(es)

autophagosome assembly intracellular protein transport ER to Golgi vesicle-mediated transport endocytosis autophagy cell migration virion assembly growth hormone secretion Rab protein signal transduction defense response to bacterium vesicle transport along microtubule interleukin-8 secretion establishment of endothelial intestinal barrier positive regulation of glycoprotein metabolic process regulation of autophagosome assembly retrograde vesicle-mediated transport, Golgi to ER Golgi organization small GTPase mediated signal transduction vesicle-mediated transport melanosome transport substrate adhesion-dependent cell spreading cilium assembly COPII vesicle coating cargo loading into COPII-coated vesicle cell-cell adhesion transport protein transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RAB1A Polyclonal Antibody

RAB1A Antibody (11671-1-AP) in ICC/IF

Product Details

11671-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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