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RAC1, RAC2 Polyclonal Antibody

1 Reference
View all (2) RAC1/2 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

OSR00269W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (IHC)

1:1,000-1:2,000
-

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 100-150 of of human RAC1 conjugated to blue carrier protein was used as the antigen
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide is homologous in rat, mouse, guinea pig, bovine, xenopus, dog, zebrafish and chicken.

Specificity of this antibody: RAC1 and RAC2.

Target Information

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Cell migration-inducing gene 5 protein; EN-7 protein; GX; p21-Rac1; p21-Rac2; Protein EN-7; Ras-like protein TC25; RAS-related C3 botulinum substrate 2; Ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); rho family, small GTP binding protein Rac1; Small G protein

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Gene Aliases: AI323801; AI452260; AL023026; D5Ertd559e; EN-7; Gx; HSPC022; MIG5; p21-Rac1; p21-Rac2; Rac; Rac-1; RAC1; RAC2; TC-25; TC25

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UniProt ID: (Human) P63000, (Human) P15153, (Mouse) P63001, (Rat) Q6RUV5, (Mouse) Q05144

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Entrez Gene ID: (Human) 5879, (Human) 5880, (Mouse) 19353, (Rat) 363875, (Rat) 366957, (Mouse) 19354

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Function(s)
GTPase activity protein binding GTP binding Rab GTPase binding enzyme binding protein kinase binding GTP-dependent protein binding thioesterase binding histone deacetylase binding Rho GDP-dissociation inhibitor binding protein kinase regulator activity nucleotide binding small GTPase immunoglobulin
Process(es)
positive regulation of protein phosphorylation auditory receptor cell morphogenesis mast cell chemotaxis epithelial cell morphogenesis movement of cell or subcellular component inflammatory response hyperosmotic response cell adhesion cell-matrix adhesion G-protein coupled receptor signaling pathway small GTPase mediated signal transduction axon guidance blood coagulation cell proliferation regulation of cell size response to wounding anatomical structure morphogenesis regulation of hydrogen peroxide metabolic process positive regulation of lamellipodium assembly regulation of fibroblast migration positive regulation of cell-substrate adhesion regulation of neuron maturation cerebral cortex radially oriented cell migration embryonic olfactory bulb interneuron precursor migration cerebral cortex GABAergic interneuron development lamellipodium assembly actin cytoskeleton organization actin filament polymerization platelet activation regulation of cell migration positive regulation of actin filament polymerization T cell costimulation ruffle organization negative regulation of interleukin-23 production substrate adhesion-dependent cell spreading positive regulation of Rho protein signal transduction intracellular signal transduction Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of apoptotic process positive regulation of phosphatidylinositol 3-kinase activity engulfment of apoptotic cell cell-cell junction organization bone resorption positive regulation of DNA replication vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway negative regulation of receptor-mediated endocytosis anatomical structure arrangement dendrite morphogenesis cell motility homeostasis of number of cells within a tissue regulation of defense response to virus by virus regulation of small GTPase mediated signal transduction positive regulation of stress fiber assembly localization within membrane positive regulation of focal adhesion assembly synaptic transmission, GABAergic Wnt signaling pathway, planar cell polarity pathway regulation of respiratory burst cellular response to mechanical stimulus semaphorin-plexin signaling pathway dopaminergic neuron differentiation protein localization to plasma membrane positive regulation of neutrophil chemotaxis cochlea morphogenesis ruffle assembly positive regulation of substrate adhesion-dependent cell spreading chemotaxis actin filament organization signal transduction positive regulation of cell proliferation regulation of cell-substrate adhesion cell projection assembly regulation of T cell proliferation regulation of mast cell degranulation regulation of protein kinase activity regulation of mast cell chemotaxis lymphocyte aggregation regulation of neutrophil migration positive regulation of protein targeting to mitochondrion endocytosis phagocytosis, engulfment cytoskeleton organization metabolic process dendrite development cell migration regulation of cell morphogenesis Rac protein signal transduction
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