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Product Details
PA5-102456
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SAA1(Accession P0DJI8), corresponding to amino acid residues F29-A79.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2815921
Product Specific Information
Antibody detects endogenous levels of total SAA1/2.
Target Information
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: SAA; SAA2; serum amyloid A 1; serum amyloid A 2; serum amyloid A protein; Serum amyloid A-1 protein; Serum amyloid A-2 protein; tumor protein p53 inducible protein 4
Gene Aliases: AW111173; PIG4; SAA; Saa-1; Saa-2; SAA1; SAA2; TP53I4
UniProt ID: (Human) P0DJI8, (Human) P02735, (Mouse) P05366, (Mouse) P05367
Entrez Gene ID: (Human) 6288, (Human) 6289, (Mouse) 20208, (Mouse) 20209
activation of MAPK activity
receptor-mediated endocytosis
acute-phase response
positive regulation of cytosolic calcium ion concentration
platelet activation
neutrophil chemotaxis
cellular protein metabolic process
innate immune response
positive regulation of cell adhesion
macrophage chemotaxis
lymphocyte chemotaxis
regulation of protein secretion
positive regulation of cytokine secretion
positive regulation of interleukin-1 secretion
negative regulation of inflammatory response
positive chemotaxis
cell chemotaxis
cholesterol metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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