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SAP97 Antibody (OSD00038W-100UL) in IHC (P)
IHC on paraffin sections of rat lung tissue using Rabbit antibody to SAP97 (2-50): OSD00038W. HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1:1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with H... View More
Product Details
OSD00038W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 2-50 of human SAP97 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: SAP97.
Target Information
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; discs, large homolog 1 (Drosophila) transcript variant 6-v1; discs, large homolog 1 (Drosophila) transcript variant 6-v2; Disks large homolog 1; DKFZp761P0818; DKFZp781B0426; Drosophila discs-large tumor suppressor homologue (synapse associated protein); E-dlg/SAP97; Embryo-dlg/synapse-associated protein 97; hDlg; presynaptic protein SAP97; SAP-97; Synapse-associated protein 97
Gene Aliases: B130052P05Rik; dJ1061C18.1.1; DLG1; DLGH1; E-dlg/SAP97; hdlg; mKIAA4187; SAP-97; SAP97
UniProt ID: (Human) Q12959, (Rat) Q62696, (Mouse) Q62402
Entrez Gene ID: (Human) 1739, (Rat) 25252, (Mouse) 13383
guanylate kinase activity
phosphoprotein phosphatase activity
protein binding
protein C-terminus binding
cytoskeletal protein binding
ligand-gated ion channel activity
potassium channel regulator activity
protein kinase binding
phosphatase binding
mitogen-activated protein kinase kinase binding
protein complex scaffold
ionotropic glutamate receptor binding
ion channel binding
L27 domain binding
cadherin binding involved in cell-cell adhesion
PDZ domain binding
kinase binding
scaffold/adaptor protein
negative regulation of transcription from RNA polymerase II promoter
branching involved in ureteric bud morphogenesis
immunological synapse formation
endothelial cell proliferation
lens development in camera-type eye
T cell cytokine production
protein dephosphorylation
actin filament organization
mitotic cell cycle checkpoint
establishment or maintenance of cell polarity
chemical synaptic transmission
nervous system development
positive regulation of cell proliferation
regulation of cell shape
viral process
single organismal cell-cell adhesion
peristalsis
positive regulation of actin filament polymerization
cortical actin cytoskeleton organization
astral microtubule organization
membrane raft organization
regulation of myelination
activation of protein kinase activity
ion transmembrane transport
cellular protein complex localization
T cell activation
negative regulation of T cell proliferation
regulation of membrane potential
amyloid precursor protein metabolic process
receptor clustering
positive regulation of potassium ion transport
cortical microtubule organization
establishment or maintenance of epithelial cell apical/basal polarity
negative regulation of mitotic cell cycle
GMP metabolic process
GDP metabolic process
reproductive structure development
embryonic skeletal system morphogenesis
smooth muscle tissue development
negative regulation of epithelial cell proliferation
establishment of centrosome localization
negative regulation of protein kinase B signaling
hard palate development
negative regulation of ERK1 and ERK2 cascade
bicellular tight junction assembly
protein localization to plasma membrane
positive regulation of establishment of protein localization to plasma membrane
receptor localization to synapse
regulation of NIK/NF-kappaB signaling
regulation of sodium ion transmembrane transport
negative regulation of p38MAPK cascade
ureteric bud development
cell adhesion
protein localization
regulation of protein localization
nucleotide phosphorylation
tissue morphogenesis
positive regulation of multicellular organism growth
positive regulation of developmental growth
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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