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Invitrogen
SELS Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Product Details
PA5-52686
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SELS. Recombinant protein control fragment (Product #RP-90222).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2647100
Product Specific Information
Immunogen sequence: EPDVVVKRQE ALAAARLKMQ EELNAQVEKH KEKLKQLEEE KRRQKIEMWD SMQEGKSYKG NAKKPQEEDS PGPSTSSVLK RKSDRKPLRG GGYNPLSGEG GGACSWRPGR
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.
Target Information
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. It participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC104346; MGC2553; Selenoprotein S; SelS; valosin-containing protein-interacting membrane protein; VCP-interacting membrane protein; VCP-interacting membrane selenoprotein
Gene Aliases: AD-015; ADO15; SBBI8; SELENOS; SELS; SEPS1; VIMP
UniProt ID: (Human) Q9BQE4
Entrez Gene ID: (Human) 55829
negative regulation of acute inflammatory response to antigenic stimulus
regulation of gluconeogenesis
ER overload response
response to glucose
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
cellular response to insulin stimulus
cellular response to oxidative stress
establishment of protein localization
cell redox homeostasis
negative regulation of glycogen biosynthetic process
negative regulation of glucose import
negative regulation of inflammatory response
negative regulation of nitric-oxide synthase biosynthetic process
response to redox state
cellular response to lipopolysaccharide
regulation of nitric oxide metabolic process
cellular oxidant detoxification
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of macrophage apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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