Proteintech

STAT2 Polyclonal Antibody

STAT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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STAT2 Antibody (16674-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer using 16674-1-AP (STAT2 antibody) at dilution of 1:50 (under 40x lens).

STAT2 Antibody in Immunoprecipitation (IP)

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Product Details

16674-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

STAT2 Fusion Protein Ag10168 (503-851 aa encoded by BC051284)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human STAT2. The calculated molecular weight of STAT2 is 98 kDa, but phosphorylated STAT2 is about 100-113 kDa.

Immunogen sequence: QFSSYVGRG LNSDQLSMLR NKLFGQNCRT EDPLLSWADF TKRESPPGKL PFWTWLDKIL ELVHDHLKDL WNDGRIMGFV SRSQERRLLK KTMSGTFLLR FSESSEGGIT CSWVEHQDDD KVLIYSVQPY TKEVLQSLPL TEIIRHYQLL TEENIPENPL RFLYPRIPRD EAFGCYYQEK VNLQERRKYL KHRLIVVSNR QVDELQQPLE LKPEPELESL ELELGLVPEP ELSLDLEPLL KAGLDLGPEL ESVLESTLEP VIEPTLCMVS QTVPEPDQGP VSQPVPEPDL PCDLRHLNTE PMEIFRNCVK IEEIMPNGDP LLAGQNTVDE VYVSRPSHFY TDGPLMPSDF (503-851 aa encoded by BC051284)

Target Information

STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The main protease of SARS-CoV-2 cleaves histone deacetylases and DCP1A, attenuating the immune defense of the interferon-stimulated genes.

The Journal of biological chemistry

Song L,Wang D,Abbas G,Li M,Cui M,Wang J,Lin Z,Zhang XE

Wed Mar 01 00:00:00 EST 2023

The main protease of SARS-CoV-2 cleaves histone deacetylases and DCP1A, attenuating the immune defense of the interferon-stimulated genes.

The Journal of biological chemistry

Song L,Wang D,Abbas G,Li M,Cui M,Wang J,Lin Z,Zhang XE

Wed Mar 01 00:00:00 EST 2023

Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.

Frontiers in immunology

Huang HX,Zhao CC,Lei XX,Zhang XY,Li YY,Lan T,Zhao BP,Lu JY,Sun WC,Lu HJ,Jin NY

Fri Jun 09 00:00:00 EDT 2023

PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression.

Research (Washington, D.C.)

Tang J,He J,Guo H,Lin H,Li M,Yang T,Wang HY,Li D,Liu J,Li L,Xia H,Zhuo Z,Miao L

Thu Apr 13 00:00:00 EDT 2023

HHLA2 Activates the JAK/STAT Signaling Pathway by Binding to TMIGD2 in Hepatocellular Carcinoma Cells.

Inflammation

Guo H,Zhang C,Tang X,Zhang T,Liu Y,Yu H,Li Y,Wang R

Mon Aug 01 00:00:00 EDT 2022

Atractylodis macrocephalae polysaccharides protect against DSS-induced intestinal injury through a novel lncRNA ITSN1-OT1.

International journal of biological macromolecules

Zong X,Xiao X,Kai L,Cheng Y,Fu J,Xu W,Wang Y,Zhao K,Jin M

Fri Jan 15 00:00:00 EST 2021

A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating β-TrCP E3 Ubiquitin Ligase.

International journal of molecular sciences

Peng T,Wonganan O,Zhang Z,Yu J,Xi R,Cao Y,Suksamrarn A,Zhang G,Wang F

Thu Mar 25 00:00:00 EDT 2021

Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.

Journal of immunology (Baltimore, Md. : 1950)

Zhang M,Fu M,Li M,Hu H,Gong S,Hu Q

Tue Sep 01 00:00:00 EDT 2020

Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.

Journal of immunology (Baltimore, Md. : 1950)

Zhang M,Fu M,Li M,Hu H,Gong S,Hu Q

Tue Sep 01 00:00:00 EDT 2020

Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.

Journal of immunology (Baltimore, Md. : 1950)

Zhang M,Fu M,Li M,Hu H,Gong S,Hu Q

Tue Sep 01 00:00:00 EDT 2020

Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.

Toxicology in vitro : an international journal published in association with BIBRA

Kang N,Cao S,Jiang B,Zhang Q,Donkor PO,Zhu Y,Qiu F,Gao X

Tue Sep 01 00:00:00 EDT 2020

Alcohol attenuates anti-HCV function of IFN-λ1 through up-regulation of PLASy expression in human hepatic cells.

Journal of medical virology

Ran M,Huang J,Liang H,Jiang J,Liang B,Ning C,Zang N,Liao W,Liu H,Qin F,Yang Q,Ho W,Ye L,Chen H

Fri Jun 01 00:00:00 EDT 2018

6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.

Toxicology and applied pharmacology

Wonganan O,He YJ,Shen XF,Wongkrajang K,Suksamrarn A,Zhang GL,Wang F

Fri Dec 01 00:00:00 EST 2017

Toxicology and applied pharmacology

Wonganan O,He YJ,Shen XF,Wongkrajang K,Suksamrarn A,Zhang GL,Wang F

Fri Dec 01 00:00:00 EST 2017

Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.

Oncotarget

Igbe I,Shen XF,Jiao W,Qiang Z,Deng T,Li S,Liu WL,Liu HW,Zhang GL,Wang F

Tue Dec 26 00:00:00 EST 2017

Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.

Oncotarget

Igbe I,Shen XF,Jiao W,Qiang Z,Deng T,Li S,Liu WL,Liu HW,Zhang GL,Wang F

Tue Dec 26 00:00:00 EST 2017

STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.

Molecular cancer research : MCR

Jackson JD,Markert JM,Li L,Carroll SL,Cassady KA

Sun May 01 00:00:00 EDT 2016

STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.

Molecular cancer research : MCR

Jackson JD,Markert JM,Li L,Carroll SL,Cassady KA

Sun May 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: interferon alpha induced transcriptional activator; MGC59816; p113; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT; STAT 2; STAT-2

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Gene Aliases: IMD44; ISGF-3; P113; STAT113; STAT2

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UniProt ID: (Human) P52630

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Entrez Gene ID: (Human) 6773

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Function(s)

DNA binding transcription factor activity, sequence-specific DNA binding signal transducer activity protein binding identical protein binding DNA-binding transcription factor

Process(es)

regulation of protein phosphorylation positive regulation of defense response to virus by host transcription, DNA-templated regulation of transcription from RNA polymerase II promoter JAK-STAT cascade defense response to virus type I interferon signaling pathway regulation of type I interferon-mediated signaling pathway regulation of mitochondrial fission mitophagy in response to mitochondrial depolarization xenophagy

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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STAT2 Polyclonal Antibody

STAT2 Antibody (16674-1-AP) in IHC (P)

Product Details

16674-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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