Proteintech

SURVIVIN Polyclonal Antibody

SURVIVIN Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 16

SURVIVIN Antibody (10508-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using SURVIVIN antibody (Product # 10508-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SURVIVIN Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SURVIVIN Antibody in Flow Cytometry (Flow)

SURVIVIN Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10508-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 102 publications 102 publications

Immunohistochemistry (IHC)

View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400

Immunocytochemistry (ICC/IF)

1:200

View 4 publications 4 publications

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Hamster, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SURVIVIN Fusion Protein Ag0788 (1-142 aa encoded by BC008718)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGAPTLPPA WQPFLKDHRI STFKNWPFLE GCACTPERMA EAGFIHCPTE NEPDLAQCFF CFKELEGWEP DDDPIEEHKK HSSGCAFLSV KKQFEELTLG EFLKLDRERA KNKIAKETNN KKKEFEETAK KVRRAIEQLA AMD (1-142 aa encoded by BC008718)

Target Information

Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family. The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of survivin’s gene expression. Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. Survivin may counteract a default induction of apoptosis in G2/M phase. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Biomaterials

Song H,Guo T,Zhao Z,Wei Y,Luo H,Weng W,Zhang R,Zhong M,Chen C,Su J,Shen W

Sat Sep 01 00:00:00 EDT 2018

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.

Cancer letters

Wang J,Tian L,Khan MN,Zhang L,Chen Q,Zhao Y,Yan Q,Fu L,Liu J

Wed Feb 28 00:00:00 EST 2018

Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.

Cancer letters

Wang J,Tian L,Khan MN,Zhang L,Chen Q,Zhao Y,Yan Q,Fu L,Liu J

Wed Feb 28 00:00:00 EST 2018

Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhu X,Li Z,Li T,Long F,Lv Y,Liu L,Liu X,Zhan Q

Fri Jun 01 00:00:00 EDT 2018

Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhu X,Li Z,Li T,Long F,Lv Y,Liu L,Liu X,Zhan Q

Fri Jun 01 00:00:00 EDT 2018

Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang C,Li T,Yan F,Cai W,Zheng J,Jiang X,Sun J

Sat Sep 01 00:00:00 EDT 2018

Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang C,Li T,Yan F,Cai W,Zheng J,Jiang X,Sun J

Sat Sep 01 00:00:00 EDT 2018

The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Cai T,Zhang C,Zhao Z,Li S,Cai H,Chen X,Cai D,Liu W,Yan Y,Xie K,Pan H,Zeng X

Wed Aug 01 00:00:00 EDT 2018

The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Cai T,Zhang C,Zhao Z,Li S,Cai H,Chen X,Cai D,Liu W,Yan Y,Xie K,Pan H,Zeng X

Wed Aug 01 00:00:00 EDT 2018

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.

Oxidative medicine and cellular longevity

Maryam A,Mehmood T,Yan Q,Li Y,Khan M,Ma T

Tue Sep 18 00:00:00 EDT 2018

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.

Oxidative medicine and cellular longevity

Maryam A,Mehmood T,Yan Q,Li Y,Khan M,Ma T

Tue Sep 18 00:00:00 EDT 2018

LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.

Biochimica et biophysica acta. Molecular basis of disease

Chen S,Wang LL,Sun KX,Liu Y,Guan X,Zong ZH,Zhao Y

Sat Sep 01 00:00:00 EDT 2018

LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.

Biochimica et biophysica acta. Molecular basis of disease

Chen S,Wang LL,Sun KX,Liu Y,Guan X,Zong ZH,Zhao Y

Sat Sep 01 00:00:00 EDT 2018

Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells.

Chemico-biological interactions

Liu L,Wang Q,Mao J,Qin T,Sun Y,Yang J,Han Y,Li L,Li Q

Tue Dec 25 00:00:00 EST 2018

Salinomycin suppresses cancer cell stemness and attenuates TGF-β-induced epithelial-mesenchymal transition of renal cell carcinoma cells.

Chemico-biological interactions

Liu L,Wang Q,Mao J,Qin T,Sun Y,Yang J,Han Y,Li L,Li Q

Tue Dec 25 00:00:00 EST 2018

Targeting HSP60 by subcutaneous injections of jetPEI/HSP60-shRNA destabilizes cytoplasmic survivin and inhibits hepatocellular carcinoma growth.

Molecular carcinogenesis

Huang YH,Lin KH,Yu JS,Wu TJ,Lee WC,Chao CC,Pan TL,Yeh CT

Sat Sep 01 00:00:00 EDT 2018

Targeting HSP60 by subcutaneous injections of jetPEI/HSP60-shRNA destabilizes cytoplasmic survivin and inhibits hepatocellular carcinoma growth.

Molecular carcinogenesis

Huang YH,Lin KH,Yu JS,Wu TJ,Lee WC,Chao CC,Pan TL,Yeh CT

Sat Sep 01 00:00:00 EDT 2018

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.

Chinese medicine

Wang Q,Zang W,Han L,Yang L,Ye S,Ouyang J,Zhang C,Bi Y,Zhang C,Bian H

Fri Apr 08 00:00:00 EDT 2022

Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.

Chinese medicine

Wang Q,Zang W,Han L,Yang L,Ye S,Ouyang J,Zhang C,Bi Y,Zhang C,Bian H

Fri Apr 08 00:00:00 EDT 2022

RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Wang X,Liu W,Wang P,Li S

Thu Nov 01 00:00:00 EDT 2018

RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Wang X,Liu W,Wang P,Li S

Thu Nov 01 00:00:00 EDT 2018

Identification of the key genes and pathways in prostate cancer.

Oncology letters

Fan S,Liang Z,Gao Z,Pan Z,Han S,Liu X,Zhao C,Yang W,Pan Z,Feng W

Thu Nov 01 00:00:00 EDT 2018

Identification of the key genes and pathways in prostate cancer.

Oncology letters

Fan S,Liang Z,Gao Z,Pan Z,Han S,Liu X,Zhao C,Yang W,Pan Z,Feng W

Thu Nov 01 00:00:00 EDT 2018

RhPDCD5 combined with dexamethasone increases antitumor activity in multiple myeloma partially via inhibiting the Wnt signalling pathway.

Clinical and experimental pharmacology & physiology

Cheng Q,Liu L,Fu Y,Zhang Y,Yang Y,Liu J

Thu Feb 01 00:00:00 EST 2018

RhPDCD5 combined with dexamethasone increases antitumor activity in multiple myeloma partially via inhibiting the Wnt signalling pathway.

Clinical and experimental pharmacology & physiology

Cheng Q,Liu L,Fu Y,Zhang Y,Yang Y,Liu J

Thu Feb 01 00:00:00 EST 2018

lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.

Molecular carcinogenesis

Du Y,Wang L,Chen S,Liu Y,Zhao Y

Sat Sep 01 00:00:00 EDT 2018

Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9.

ACS synthetic biology

Wang W,Zheng W,Hu F,He X,Wu D,Zhang W,Liu H,Ma X

Fri May 18 00:00:00 EDT 2018

Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9.

ACS synthetic biology

Wang W,Zheng W,Hu F,He X,Wu D,Zhang W,Liu H,Ma X

Fri May 18 00:00:00 EDT 2018

[Knocking down fascin inhibits cervical cancer cell proliferation and tumorigenesis in nude mice].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

Li X,Li S,Wang X,Zhao S,Liu H

Sun Dec 30 00:00:00 EST 2018

Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.

Cancer medicine

Wu Z,Zhu Q,Yin Y,Kang D,Cao R,Tian Q,Zhang Y,Lu S,Liu P

Sun Apr 01 00:00:00 EDT 2018

Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.

Cancer medicine

Wu Z,Zhu Q,Yin Y,Kang D,Cao R,Tian Q,Zhang Y,Lu S,Liu P

Sun Apr 01 00:00:00 EDT 2018

RELM-β promotes human pulmonary artery smooth muscle cell proliferation via FAK-stimulated surviving.

Experimental cell research

Lin C,Li X,Luo Q,Yang H,Li L,Zhou Q,Li Y,Tang H,Wu L

Wed Feb 01 00:00:00 EST 2017

RELM-β promotes human pulmonary artery smooth muscle cell proliferation via FAK-stimulated surviving.

Experimental cell research

Lin C,Li X,Luo Q,Yang H,Li L,Zhou Q,Li Y,Tang H,Wu L

Wed Feb 01 00:00:00 EST 2017

Anticancer effect of PP31J isolated from Physalis pubescens L. in human cervical carcinoma cells.

American journal of translational research

Zeng W,Wang Q,Chen L,Huang L,Zhao X

Tue Sep 29 00:00:00 EDT 2020

Anticancer effect of PP31J isolated from Physalis pubescens L. in human cervical carcinoma cells.

American journal of translational research

Zeng W,Wang Q,Chen L,Huang L,Zhao X

Tue Sep 29 00:00:00 EDT 2020

Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.

Oncology letters

Yan Z,Feng J,Peng J,Lai Z,Zhang L,Jin Y,Yang H,Chen W,Lin J

Fri Dec 01 00:00:00 EST 2017

Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.

Oncology letters

Yan Z,Feng J,Peng J,Lai Z,Zhang L,Jin Y,Yang H,Chen W,Lin J

Fri Dec 01 00:00:00 EST 2017

Inhibition of store-operated Ca²⁺ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.

Oncology letters

Huang W,Ren C,Huang G,Liu J,Liu W,Wang L,Zhu B,Feng X,Shi J,Li J,Xia X,Jia W,Chen J,Chen Y,Jiang X

Wed Feb 01 00:00:00 EST 2017

Inhibition of store-operated Ca²⁺ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.

Oncology letters

Huang W,Ren C,Huang G,Liu J,Liu W,Wang L,Zhu B,Feng X,Shi J,Li J,Xia X,Jia W,Chen J,Chen Y,Jiang X

Wed Feb 01 00:00:00 EST 2017

PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Experimental and therapeutic medicine

Xu X,Cui Y,Cao L,Zhang Y,Yin Y,Hu X

Mon May 01 00:00:00 EDT 2017

PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Experimental and therapeutic medicine

Xu X,Cui Y,Cao L,Zhang Y,Yin Y,Hu X

Mon May 01 00:00:00 EDT 2017

Decreased calpain activity in chronic myeloid leukemia impairs apoptosis by increasing survivin in myeloid progenitors and xiap1 in differentiating granulocytes.

Oncotarget

Huang W,Bei L,Hjort EE,Eklund EA

Tue Aug 01 00:00:00 EDT 2017

In vitro anticancer activities of osthole against renal cell carcinoma cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Liu L,Mao J,Wang Q,Zhang Z,Wu G,Tang Q,Zhao B,Li L,Li Q

Sun Oct 01 00:00:00 EDT 2017

CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.

Cell death & disease

Mao X,Li P,Wang Y,Liang Z,Liu J,Li J,Jiang Y,Bao G,Li L,Zhu B,Ren Y,Zhao X,Zhang J,Liu Y,Yang J,Liu P

Thu Jan 12 00:00:00 EST 2017

CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.

Cell death & disease

Mao X,Li P,Wang Y,Liang Z,Liu J,Li J,Jiang Y,Bao G,Li L,Zhu B,Ren Y,Zhao X,Zhang J,Liu Y,Yang J,Liu P

Thu Jan 12 00:00:00 EST 2017

Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma.

Oncotarget

Zheng M,Xu H,Liao XH,Chen CP,Zhang AL,Lu W,Wang L,Yang D,Wang J,Liu H,Zhou XZ,Lu KP

Tue May 02 00:00:00 EDT 2017

Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma.

Oncotarget

Zheng M,Xu H,Liao XH,Chen CP,Zhang AL,Lu W,Wang L,Yang D,Wang J,Liu H,Zhou XZ,Lu KP

Tue May 02 00:00:00 EDT 2017

Multifunctional WS₂ @Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.

Advanced healthcare materials

Zhang C,Yong Y,Song L,Dong X,Zhang X,Liu X,Gu Z,Zhao Y,Hu Z

Tue Nov 01 00:00:00 EDT 2016

Multifunctional WS₂ @Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.

Advanced healthcare materials

Zhang C,Yong Y,Song L,Dong X,Zhang X,Liu X,Gu Z,Zhao Y,Hu Z

Tue Nov 01 00:00:00 EDT 2016

Multifunctional WS₂ @Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.

Advanced healthcare materials

Zhang C,Yong Y,Song L,Dong X,Zhang X,Liu X,Gu Z,Zhao Y,Hu Z

Tue Nov 01 00:00:00 EDT 2016

Multifunctional WS₂ @Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.

Advanced healthcare materials

Zhang C,Yong Y,Song L,Dong X,Zhang X,Liu X,Gu Z,Zhao Y,Hu Z

Tue Nov 01 00:00:00 EDT 2016

Inhibitory effect on the proliferation of human heptoma induced by cell-permeable manganese superoxide dismutase.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Guo H,Zhang N,Liu D,Wang P,Ma X

Sat Oct 01 00:00:00 EDT 2016

Inhibitory effect on the proliferation of human heptoma induced by cell-permeable manganese superoxide dismutase.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Guo H,Zhang N,Liu D,Wang P,Ma X

Sat Oct 01 00:00:00 EDT 2016

A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells.

Oncotarget

Fu ZG,Wang L,Cui HY,Peng JL,Wang SJ,Geng JJ,Liu JD,Feng F,Song F,Li L,Zhu P,Jiang JL,Chen ZN

Tue Feb 23 00:00:00 EST 2016

A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells.

Oncotarget

Fu ZG,Wang L,Cui HY,Peng JL,Wang SJ,Geng JJ,Liu JD,Feng F,Song F,Li L,Zhu P,Jiang JL,Chen ZN

Tue Feb 23 00:00:00 EST 2016

KLF5 mediates vascular remodeling via HIF-1α in hypoxic pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Li X,He Y,Xu Y,Huang X,Liu J,Xie M,Liu X

Mon Feb 15 00:00:00 EST 2016

Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.

Circulation research

Cotroneo E,Ashek A,Wang L,Wharton J,Dubois O,Bozorgi S,Busbridge M,Alavian KN,Wilkins MR,Zhao L

Fri May 08 00:00:00 EDT 2015

Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.

Circulation research

Cotroneo E,Ashek A,Wang L,Wharton J,Dubois O,Bozorgi S,Busbridge M,Alavian KN,Wilkins MR,Zhao L

Fri May 08 00:00:00 EDT 2015

Oral delivery of shRNA based on amino acid modified chitosan for improved antitumor efficacy.

Biomaterials

Zheng H,Tang C,Yin C

Sun Nov 01 00:00:00 EDT 2015

Oral delivery of shRNA based on amino acid modified chitosan for improved antitumor efficacy.

Biomaterials

Zheng H,Tang C,Yin C

Sun Nov 01 00:00:00 EDT 2015

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells.

Autophagy

Zhao X,Fang Y,Yang Y,Qin Y,Wu P,Wang T,Lai H,Meng L,Wang D,Zheng Z,Lu X,Zhang H,Gao Q,Zhou J,Ma D

Tue Sep 13 00:00:00 EDT 2016

Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells.

Autophagy

Zhao X,Fang Y,Yang Y,Qin Y,Wu P,Wang T,Lai H,Meng L,Wang D,Zheng Z,Lu X,Zhang H,Gao Q,Zhou J,Ma D

Tue Sep 13 00:00:00 EDT 2016

Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.

International journal of oncology

Li X,Liu X,Xu Y,He Y,Liu J,Xie M

Sun Feb 01 00:00:00 EST 2015

Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.

International journal of oncology

Li X,Liu X,Xu Y,He Y,Liu J,Xie M

Sun Feb 01 00:00:00 EST 2015

Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.

International journal of oncology

Shan X,Tian LL,Zhang YM,Wang XQ,Yan Q,Liu JW

Sat Aug 01 00:00:00 EDT 2015

Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.

International journal of oncology

Shan X,Tian LL,Zhang YM,Wang XQ,Yan Q,Liu JW

Sat Aug 01 00:00:00 EDT 2015

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Medical oncology (Northwood, London, England)

Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C

Wed Apr 01 00:00:00 EDT 2015

DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.

Medical oncology (Northwood, London, England)

Huang W,Liu J,Feng X,Chen H,Zeng L,Huang G,Liu W,Wang L,Jia W,Chen J,Ren C

Wed Apr 01 00:00:00 EDT 2015

The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis.

The Journal of biological chemistry

Yu C,Cui S,Zong C,Gao W,Xu T,Gao P,Chen J,Qin D,Guan Q,Liu Y,Fu Y,Li X,Wang X

Fri Aug 21 00:00:00 EDT 2015

The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis.

The Journal of biological chemistry

Yu C,Cui S,Zong C,Gao W,Xu T,Gao P,Chen J,Qin D,Guan Q,Liu Y,Fu Y,Li X,Wang X

Fri Aug 21 00:00:00 EDT 2015

RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.

Genes & cancer

Jin Y,Cao B,Zhang M,Zhan Q,Herman JG,Yu M,Guo M

Fri May 01 00:00:00 EDT 2015

RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.

Genes & cancer

Jin Y,Cao B,Zhang M,Zhan Q,Herman JG,Yu M,Guo M

Fri May 01 00:00:00 EDT 2015

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Drug design, development and therapy

Yao Z,Sun B,Hong Q,Yan J,Mu D,Li J,Sheng H,Guo H

Thu Sep 15 00:00:00 EDT 2016

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Drug design, development and therapy

Yao Z,Sun B,Hong Q,Yan J,Mu D,Li J,Sheng H,Guo H

Thu Sep 15 00:00:00 EDT 2016

Enhanced antitumor efficacy of folate modified amphiphilic nanoparticles through co-delivery of chemotherapeutic drugs and genes.

Biomaterials

Yu B,Tang C,Yin C

Fri Aug 01 00:00:00 EDT 2014

Enhanced antitumor efficacy of folate modified amphiphilic nanoparticles through co-delivery of chemotherapeutic drugs and genes.

Biomaterials

Yu B,Tang C,Yin C

Fri Aug 01 00:00:00 EDT 2014

KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1α.

International journal of oncology

Li X,Liu X,Xu Y,Liu J,Xie M,Ni W,Chen S

Wed Oct 01 00:00:00 EDT 2014

KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1α.

International journal of oncology

Li X,Liu X,Xu Y,Liu J,Xie M,Ni W,Chen S

Wed Oct 01 00:00:00 EDT 2014

High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting.

Nanotechnology

Zhang MZ,Li C,Fang BY,Yao MH,Ren QQ,Zhang L,Zhao YD

Fri Jun 27 00:00:00 EDT 2014

High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting.

Nanotechnology

Zhang MZ,Li C,Fang BY,Yao MH,Ren QQ,Zhang L,Zhao YD

Fri Jun 27 00:00:00 EDT 2014

Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

Wu J,Chen W,Yin Y,Zheng Z,Zou G

Sun Jun 01 00:00:00 EDT 2014

Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

Wu J,Chen W,Yin Y,Zheng Z,Zou G

Sun Jun 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: Apoptosis inhibitor 4; Apoptosis inhibitor survivin; Baculoviral IAP repeat-containing protein 5; BIRC 5; EPR 1; survivin; survivin variant 3 alpha; SVV; TIAP

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Gene Aliases: AAC-11; AP14; API4; BIRC5; EPR-1; IAP4; survivin40; TIAP

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UniProt ID: (Human) O15392, (Rat) Q9JHY7, (Mouse) O70201

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Entrez Gene ID: (Human) 332, (Rat) 64041, (Mouse) 11799

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Function(s)

ubiquitin-protein transferase activity cysteine-type endopeptidase inhibitor activity protein binding microtubule binding Ran GTPase binding enzyme binding identical protein binding metal ion binding chaperone binding molecular_function zinc ion binding tubulin binding protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein heterodimerization activity cofactor binding peptidase inhibitor activity

Process(es)

G2/M transition of mitotic cell cycle microtubule cytoskeleton organization transcription, DNA-templated protein phosphorylation chromosome segregation regulation of mitotic cell cycle regulation of signal transduction protein ubiquitination protein complex localization positive regulation of exit from mitosis cellular response to stem cell factor stimulus response to drug negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to peptide hormone negative regulation of neuron apoptotic process positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of mitotic cell cycle cell division establishment of chromosome localization response to glucocorticoid regulation of insulin secretion involved in cellular response to glucose stimulus regulation of type B pancreatic cell proliferation cellular response to ethanol mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process sister chromatid cohesion positive regulation of cell proliferation protein sumoylation regulation of apoptotic process cytokinesis regulation of transcription, DNA-templated cell cycle mitotic nuclear division embryo development negative regulation of peptidase activity spindle checkpoint

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SURVIVIN Polyclonal Antibody

SURVIVIN Antibody (10508-1-AP) in ICC/IF

Product Details

10508-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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