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Stat2 Antibody (200-301-B65) in IHC (P)
Rocklands anti-Stat2 monoclonal antibody was used at a 2.5 µg/mL to detect Stat2 in squamous epithelium from human skin (40X) showing moderate to strong nuclear and faint to moderate cytoplasmic staining (image). Expression of Stat2 is expected to be cytoplasmic, and nuclear upon activation. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear co... View More
Product Details
200-301-B65
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
19G8.H2.H6
Immunogen
This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues near the carboxy terminus of mouse STAT2 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Directed against human STAT2 protein. A BLAST analysis was used to suggest cross-reactivity with STAT2 protein from human, rat (73%) and mouse (76%), sources based on homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
Target Information
STAT2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: interferon alpha induced transcriptional activator; MGC59816; p113; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT; STAT 2; STAT-2
Gene Aliases: 1600010G07Rik; AW496480; IMD44; ISGF-3; P113; STAT113; STAT2
UniProt ID: (Human) P52630
Entrez Gene ID: (Human) 6773, (Mouse) 20847
regulation of protein phosphorylation
positive regulation of defense response to virus by host
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
JAK-STAT cascade
defense response to virus
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
regulation of mitochondrial fission
mitophagy in response to mitochondrial depolarization
xenophagy
regulation of transcription, DNA-templated
signal transduction
Performance Guarantee
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