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Product Details
MA5-32953
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
2G4
Immunogen
Synthetic peptide, corresponding to the N-terminus of Human TAB1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2802587
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. It can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta activated kinase-1 binding protein-1; MGC57664; mitogen activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; RP3-407F17.2; TAB1beta; TAK1-binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
Gene Aliases: 2310012M03Rik; 3'-Tab1; b2b449Clo; MAP3K7IP1; TAB1
UniProt ID: (Human) Q15750, (Mouse) Q8CF89
Entrez Gene ID: (Human) 10454, (Mouse) 66513, (Rat) 315139
activation of MAPKKK activity
activation of MAPK activity
in utero embryonic development
stimulatory C-type lectin receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
heart morphogenesis
cardiac septum development
protein dephosphorylation
transforming growth factor beta receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
JNK cascade
lung development
aorta development
Fc-epsilon receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
coronary vasculature development
nucleotide-binding oligomerization domain containing signaling pathway
positive regulation of MAP kinase activity
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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