Proteintech

TAB2 Polyclonal Antibody

TAB2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

TAB2 Antibody (14410-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using MAP3K7IP2 antibody 14410-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

TAB2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TAB2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14410-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TAB2 Fusion Protein Ag5742 (344-693 aa encoded by BC035910)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SGPRTSSTS SSVNSQTLNR NQPTVYIAAS PPNTDELMSR SQPKVYISAN AATGDEQVMR NQPTLFISTN SGASAASRNM SGQVSMGPAF IHHHPPKSRA IGNNSATSPR VVVTQPNTKY TFKITVSPNK PPAVSPGVVS PTFELTNLLN HPDHYVETEN IQHLTDPTLA HVDRISETRK LSMGSDDAAY TQALLVHQKA RMERLQRELE IQKKKLDKLK SEVNEMENNL TRRRLKRSNS ISQIPSLEEM QQLRSCNRQL QIDIDCLTKE IDLFQARGPH FNPSAIHNFY DNIGFVGPVP PKPKDQRSII KTPKTQDTED DEGAQWNCTA CTFLNHPALI RCEQCEMPRH F (344-693 aa encoded by BC035910)

Target Information

TAB2 is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutively interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1/TAB2/NF-κB pathway.

The ocular surface

Wang L,Wang X,Chen Q,Wei Z,Xu X,Han D,Zhang Y,Chen Z,Liang Q

Sat Apr 01 00:00:00 EDT 2023

Tabersonine alleviates obesity-induced cardiomyopathy by binding to Transforming growth factor activated kinase 1 (TAK1) and inhibiting TAK1-mediated inflammation.

Phytotherapy research : PTR

Chen Y,Lin W,Chen P,Ye B,Luo W,Wang X,Huang W,Wu G,Liang G

Wed Mar 01 00:00:00 EST 2023

microRNA-149-5p mediates the PM_2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro.

Cell biology and toxicology

Li Q,Li S,Xu C,Zhao J,Hou L,Jiang F,Zhu Z,Wang Y,Tian L

Thu Jun 01 00:00:00 EDT 2023

BMSCs mediates endothelial cell autophagy by upregulating miR-155-5p to alleviate ventilator-induced lung injury.

Journal of biochemical and molecular toxicology

Lin X,Yu T,Luo J,Chen L,Liu Y,Xu J,Chen L,Lin Q,Bao Y,Xu L

Fri Jul 01 00:00:00 EDT 2022

TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells.

Stem cells international

Zhou Y,Liao Y,Zhang C,Liu J,Wang W,Huang J,Du Q,Liu T,Zou Q,Huang H,Liu P,Ooi S,Chen R,Xia M,Jiang H,Xu M,Pan Y,Yao S

Tue Jul 27 00:00:00 EDT 2021

TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells.

Stem cells international

Zhou Y,Liao Y,Zhang C,Liu J,Wang W,Huang J,Du Q,Liu T,Zou Q,Huang H,Liu P,Ooi S,Chen R,Xia M,Jiang H,Xu M,Pan Y,Yao S

Tue Jul 27 00:00:00 EDT 2021

miR-155 and miR-146a collectively regulate meningitic Escherichia coli infection-mediated neuroinflammatory responses.

Journal of neuroinflammation

Yang B,Yang R,Xu B,Fu J,Qu X,Li L,Dai M,Tan C,Chen H,Wang X

Thu May 13 00:00:00 EDT 2021

In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin.

The Korean journal of internal medicine

Sun X,Kang Y,Xue S,Zou J,Xu J,Tang D,Qin H

Mon Mar 01 00:00:00 EST 2021

In vivo therapeutic success of MicroRNA-155 antagomir in a mouse model of pulmonary fibrosis induced by bleomycin.

The Korean journal of internal medicine

Sun X,Kang Y,Xue S,Zou J,Xu J,Tang D,Qin H

Mon Mar 01 00:00:00 EST 2021

Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.

Frontiers in immunology

Deng F,Xu G,Cheng Z,Huang Y,Ma C,Luo C,Yu C,Wang J,Xu X,Liu S,Zhu Y

Mon Jun 28 00:00:00 EDT 2021

Analysis of lncRNA, miRNA and mRNA-associated ceRNA networks and identification of potential drug targets for drug-resistant non-small cell lung cancer.

Journal of Cancer

Kong X,Hu S,Yuan Y,Du Y,Zhu Z,Song Z,Lu S,Zhao C,Yan D

Mon Sep 28 00:00:00 EDT 2020

Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing.

Nature communications

Sheng C,Yao C,Wang Z,Chen H,Zhao Y,Xu D,Huang H,Huang W,Chen S

Mon Oct 22 00:00:00 EDT 2018

Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing.

Nature communications

Sheng C,Yao C,Wang Z,Chen H,Zhao Y,Xu D,Huang H,Huang W,Chen S

Mon Oct 22 00:00:00 EDT 2018

Theissenolactone C Exhibited Ocular Protection of Endotoxin-Induced Uveitis by Attenuating Ocular Inflammatory Responses and Glial Activation.

Frontiers in pharmacology

Lin FL,Ho JD,Cheng YW,Chiou GCY,Yen JL,Chang HM,Lee TH,Hsiao G

Thu Oct 01 00:00:00 EDT 2020

Theissenolactone C Exhibited Ocular Protection of Endotoxin-Induced Uveitis by Attenuating Ocular Inflammatory Responses and Glial Activation.

Frontiers in pharmacology

Lin FL,Ho JD,Cheng YW,Chiou GCY,Yen JL,Chang HM,Lee TH,Hsiao G

Thu Oct 01 00:00:00 EDT 2020

An Interaction Landscape of Ubiquitin Signaling.

Molecular cell

Zhang X,Smits AH,van Tilburg GB,Jansen PW,Makowski MM,Ovaa H,Vermeulen M

Thu Mar 02 00:00:00 EST 2017

An Interaction Landscape of Ubiquitin Signaling.

Molecular cell

Zhang X,Smits AH,van Tilburg GB,Jansen PW,Makowski MM,Ovaa H,Vermeulen M

Thu Mar 02 00:00:00 EST 2017

MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-β-Activated Protein Kinase 1 Binding Protein 2.

Frontiers in immunology

Hussain T,Zhao D,Shah SZA,Wang J,Yue R,Liao Y,Sabir N,Yang L,Zhou X

Mon Mar 09 00:00:00 EDT 2020

Frontiers in immunology

Hussain T,Zhao D,Shah SZA,Wang J,Yue R,Liao Y,Sabir N,Yang L,Zhou X

Mon Mar 09 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: FLJ21885; mitogen activated protein kinase kinase kinase 7 interacting protein 2; mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; OTTHUMP00000017388; TAB-2; Tak1 binding protein 2; TAK1-binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2

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Gene Aliases: 1110030N06Rik; A530078N03Rik; CHTD2; KIAA0733; MAP3K7IP2; mKIAA0733; TAB-2; TAB2

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UniProt ID: (Human) Q9NYJ8, (Mouse) Q99K90

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Entrez Gene ID: (Human) 23118, (Mouse) 68652, (Rat) 308267

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Function(s)

protein binding zinc ion binding K63-linked polyubiquitin binding metal ion binding

Process(es)

heart development positive regulation of protein kinase activity biological_process positive regulation of I-kappaB kinase/NF-kappaB signaling activation of MAPK activity stimulatory C-type lectin receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway I-kappaB kinase/NF-kappaB signaling JNK cascade negative regulation of autophagy Fc-epsilon receptor signaling pathway T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity nucleotide-binding oligomerization domain containing signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TAB2 Polyclonal Antibody

TAB2 Antibody (14410-1-AP) in ICC/IF

Product Details

14410-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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