Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 1
TACR3 Antibody (PA5-96611) in WB
Western blot analysis of TACR3 in extracts of various cell lines. Samples were incubated with TACR3 Polyclonal antibody (Product # PA5-96611) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96611
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 356-465 of human TACR3 (NP_0010501)
Conjugate
Form
Liquid
Concentration
2.2 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808413
Product Specific Information
Immunogen sequence: YCCLNKRFRA GFKRAFRWCP FIKVSSYDEL ELKTTRFHPN RQSSMYTVTR MESMTVVFDP NDADTTRSSR KKRATPRDPS FNGCSRRNSK SASATSSFIS SPYTSVDEYS; Positive Samples: HL-60, Human placenta; Cellular Location: Cell membrane, Multi-pass membrane protein
Target Information
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: neurokinin 3 receptor; Neurokinin B; Neurokinin B receptor; neurokinin beta receptor; neuromedin K receptor; Neuromedin K receptor (Neurokinin B/Tachikin 3); Neuromedin-K receptor; NK-3 receptor; NK-3R; Nk3 receptor; NK3R TAC3R; NKR; Nmk-r; tachikin receptor 3; Tachykinin receptor 3
Gene Aliases: HH11; NK-3R; NK3R; NKR; Nmkr; TAC3R; TAC3RL; TACR3
UniProt ID: (Human) P29371, (Mouse) P47937, (Rat) P16177
Entrez Gene ID: (Human) 6870, (Mouse) 21338, (Rat) 24808
tachykinin receptor signaling pathway
aging
positive regulation of heart rate
response to estradiol
regulation of dopamine metabolic process
response to cocaine
hyperosmotic salinity response
response to morphine
positive regulation of blood pressure
regulation of feeding behavior
positive regulation of uterine smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support