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Product Details
PA5-101171
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TAF5(Accession Q15542), corresponding to amino acid residues E391-I441.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850614
Product Specific Information
Antibody detects endogenous levels of total TAF5.
Target Information
TFIID is a general transcription factor which initiates preinitiation complex assembly through direct interaction with the TATA promoter element. It is a multisubunit complex consisting of a small TATA-binding polypeptide andother TATA-binding protein (TBP)-associated factors (TAFs). Although native TFIID can mediate both activator-independent (basal) and activator-dependent transcription in reconstituted systems, TBP can mediate only basal transcription. TAF II p100 (TBP-associated factor II100), also known as TAF5 or TAFII100, is the third largest subunit of human TFIID. It contains six WD40 repeats at the C-terminus and has an N-terminus capable of forming a flexible dimer. TAF II p100 plays an important role in forming the scaffold that is crucial for the assembly of the TFIID complex. TAF II p100 may also be involved in the stabilization of TAF interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: TAF(II)100; TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa; TAFII-100; TAFII100; TATA box binding protein (TBP)-associated factor 2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TATA box binding protein associated factor 5; Tbp-associated factor 5; transcription initiation factor TFIID 100 kD subunit; Transcription initiation factor TFIID 100 kDa subunit; Transcription initiation factor TFIID subunit 5
Gene Aliases: 6330528C20Rik; AV117817; TAF(II)100; TAF2D; TAF5; TAFII-100; TAFII100
UniProt ID: (Human) Q15542, (Mouse) Q8C092
Entrez Gene ID: (Human) 6877, (Mouse) 226182
DNA-templated transcription, initiation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
viral process
chromatin modification
histone acetylation
snRNA transcription from RNA polymerase II promoter
regulation of signal transduction by p53 class mediator
transcription, DNA-templated
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