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Product Details
PA5-88298
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 110-325 of human TAK1 (NP_6633041)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804810
Product Specific Information
Immunogen sequence: GSLYNVLHGA EPLPYYTAAH AMSWCLQCSQ GVAYLHSMQP KALIHRDLKP PNLLLVAGGT VLKICDFGTA CDIQTHMTNN KGSAAWMAPE VFEGSNYSEK CDVFSWGIIL WEVITRRKPF DEIGGPAFRI MWAVHNGTRP PLIKNLPKPI ESLMTRCWSK DPSQRPSMEE IVKIMTHLMR YFPGADEPLQ YPCQYSDEGQ SNSATSTGSF MDIAST
Positive Samples: Jurkat, K-562, Mouse liver, Mouse kidney; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein
Target Information
TAK1 (also known as MAP3K7), a part of the serine/threonine kinase family, is a versatile protein with many signaling functions. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin beta1 and integrin beta5, promoting proper wound healing. TAK1 also plays an essential role in IKK activation in numerous signaling pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination. In this process, TAB2/3 binds to the C-terminal region of TAK1 and becomes polyubiquitinated, TAK1 is autophosphorylated at Thr178, Thr184, Thr187 and Ser192, and finally TAK1 phosphorylates IKK- beta. Additionally, TAK1 represses human telomerase reverse transcriptase suggesting a role in regulation of cell lifespan.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: M3K7; mitogen activated protein kinase kinase kinase 7; Mitogen-activated protein kinase kinase kinase 7; RP1-154G14.1; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1
Gene Aliases: B430101B05; C87327; MAP3K7; MEKK7; TAK1; TGF1a
UniProt ID: (Human) O43318, (Mouse) Q62073, (Rat) P0C8E4
Entrez Gene ID: (Human) 6885, (Mouse) 26409, (Rat) 313121
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
scaffold protein binding
nucleotide binding
MAP kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
activation of MAPKK activity
activation of MAPK activity
stimulatory C-type lectin receptor signaling pathway
positive regulation of T cell cytokine production
MyD88-dependent toll-like receptor signaling pathway
transcription, DNA-templated
apoptotic process
transforming growth factor beta receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
I-kappaB phosphorylation
JNK cascade
positive regulation of interleukin-2 production
Fc-epsilon receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
histone H3 acetylation
T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
stress-activated MAPK cascade
nucleotide-binding oligomerization domain containing signaling pathway
MAPK cascade
angiogenesis
neural tube formation
regulation of transcription, DNA-templated
protein phosphorylation
phosphorylation
positive regulation of JNK cascade
negative regulation of necroptotic process
negative regulation of ripoptosome assembly involved in necroptotic process
regulation of reactive oxygen species metabolic process
negative regulation of reactive oxygen species metabolic process
negative regulation of apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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