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Product Details
26250-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TAOK1 Fusion Protein Ag22461 (889-1001 aa encoded by BC133039)
Conjugate
Form
Liquid
Concentration
0.48 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NMVLSNLSP EAFSHSYPGA SGWSHNPTGG PGPHWGHPMG GPPQAWGHPM QGGPQPWGHP SGPMQGVPRG SSMGVRNSPQ ALRRTASGGR TEQGMSRSTS VTSQISNGSH MSYT (889-1001 aa encoded by BC133039)
Target Information
TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs). The activation of and binding to MEK3 by TAOK1 implicates TAOK1 in the regulation of the p38-containing stress-responsive MAP kinase pathway. A microtubule affinity-regulating kinase, TAOK1 (also known as MARKK) is an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay. TAOK1 is involved in various processes such as p38/MAPK14 stress-activated MAPK cascase, DNA damage response, and regulations of cytoskeleton stability. It phosphorylates MAP2K3, MAP2K6, and MARK2. TAOK1 acts as an activator of the p38/MAPK cascade by mediating phosphorylation and subsequent activation of the upsteam MAP2K3 and MAP2K6 kinases. It is involved in G-protein couples receptor signaling to p38/MAPK14. In response to DNA damage, TAOK1, is involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade by phosphorylaton of MAP2K3 and MAP2K6. In addition, it acts as a regulator of cytoskeleton stability and a regulator of apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ14314; h hTAOK1; H KIAA1361; hKFC-B; Kinase from chicken homolog B; MARK Kinase; MARKK; microtubule affinity regulating kinase kinase; prostate-derived STE20-like kinase 2; Prostate-derived sterile 20-like kinase 2; PSK-2; serine/threonine protein kinase TAO1 homolog; Serine/threonine-protein kinase TAO1; STE20-like kinase PSK2; tao; TAOK1; Thousand and one amino acid protein 1; Thousand and one amino acid protein kinase 1
Gene Aliases: 2810468K05Rik; AU020252; D130018F14Rik; hKFC-B; hTAOK1; KFC-B; KIAA1361; MAP3K16; MARKK; mKIAA1361; PSK-2; PSK2; TAO1; TAOK1
UniProt ID: (Human) Q7L7X3, (Mouse) Q5F2E8
Entrez Gene ID: (Human) 57551, (Mouse) 216965
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
nucleotide binding
MAP kinase kinase kinase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
protein kinase activator activity
non-receptor serine/threonine protein kinase
DNA repair
protein phosphorylation
cellular response to DNA damage stimulus
sister chromatid cohesion
signal transduction by protein phosphorylation
G2 DNA damage checkpoint
spindle checkpoint
positive regulation of stress-activated MAPK cascade
positive regulation of JNK cascade
regulation of cytoskeleton organization
execution phase of apoptosis
MAPK cascade
activation of MAPKK activity
apoptotic process
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
regulation of apoptotic process
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