Proteintech

TBK1 Polyclonal Antibody

TBK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TBK1 Antibody (28397-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 28397-1-AP (TBK1 antibody) at dilution of 1:100 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

28397-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

View 21 publications 21 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TBK1 Fusion Protein Ag28894

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

433 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.

Experimental lung research

Peng M,Li X,Zhang X,Peng L

Sat Dec 16 00:00:00 EST 2023

A role of STING signaling in obesity-induced lung inflammation.

International journal of obesity (2005)

Qi Y,Wu Z,Chen D,Zhu L,Yang Y

Sat Apr 01 00:00:00 EDT 2023

Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.

Journal of nanobiotechnology

Jing B,Guo F,An R,Gao Y,Li Y,Xie Y,Wang J,Chen Y,Li H,Gao T,Jin Q,Zhang L,Xie M

Thu Feb 02 00:00:00 EST 2023

mascRNA alleviates STING-TBK1 signaling-mediated immune response through promoting ubiquitination of STING.

Molecular immunology

Hu Y,Li X,Wang D,Mao X

Wed Feb 01 00:00:00 EST 2023

African Swine Fever Virus H240R Protein Inhibits the Production of Type I Interferon through Disrupting the Oligomerization of STING.

Journal of virology

Ye G,Liu H,Liu X,Chen W,Li J,Zhao D,Wang G,Feng C,Zhang Z,Zhou Q,Zheng J,Bu Z,Weng C,Huang L

Thu Sep 28 00:00:00 EDT 2023

Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Wen J,Qin S,Li Y,Zhang P,Zhan X,Fang M,Shi C,Mu W,Kan W,Zhao J,Hui S,Hou M,Li H,Xiao X,Xu G,Bai Z

Mon May 01 00:00:00 EDT 2023

Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.

Journal of neurology

Zhao X,Yu M,Zhao Y,Zheng Y,Meng L,Du K,Xie Z,Lv H,Zhang W,Liu J,Wang Q,Yuan Y,Wang Z,Deng J

Thu Sep 01 00:00:00 EDT 2022

Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.

BioMed research international

He X,Xiao Y,Liu S,Deng R,Li Z,Zhu X

Mon Sep 26 00:00:00 EDT 2022

Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.

Journal of clinical laboratory analysis

Zhou M,Cheng X,Zhu W,Jiang J,Zhu S,Wu X,Liu M,Fang Q

Sat Oct 01 00:00:00 EDT 2022

STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment.

Cancer cell international

Pu Z,Liu J,Liu Z,Peng F,Zhu Y,Wang X,He J,Yi P,Hu X,Fan X,Chen J

Wed Oct 12 00:00:00 EDT 2022

QKI deficiency in macrophages protects mice against JEV infection by regulating cell migration and antiviral response.

Molecular immunology

Deng L,Wang W,Bian P,Wu M,Wang L,Lei Y,Lu Z,Zhai D

Mon Aug 01 00:00:00 EDT 2022

Identification of highly specific antibodies for Serine/threonine-protein kinase TBK1 for use in immunoblot, immunoprecipitation and immunofluorescence.

F1000Research

Alshafie W,Fotouhi M,Shlaifer I,Ayoubi R,Edwards AM,Durcan TM,McPherson PS,Laflamme C

Wed Dec 07 00:00:00 EST 2022

IKKε protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury.

Biochemical and biophysical research communications

Chen G,Xu Y,Fan R,Liu Y,Yao Y,Jiang H,Wu Q,Li L,Chen W,Chen X

Sat Jan 22 00:00:00 EST 2022

eIF4A3 Promotes RNA Viruses' Replication by Inhibiting Innate Immune Responses.

Journal of virology

Gao Q,Jiang M,Zhao Y,Li G,Yang C,Ren C,Jin M,Chen H,Zhou H

Wed Nov 23 00:00:00 EST 2022

The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.

Experimental eye research

Han F,Guo H,Wang L,Zhang Y,Sun L,Dai C,Wu X

Fri Jan 01 00:00:00 EST 2021

PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Zhang N,Gao Y,Zeng Z,Luo Y,Jiang X,Zhang J,Li J,Zhang J,Gong Y,Xie C

Wed Sep 01 00:00:00 EDT 2021

A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.

Signal transduction and targeted therapy

Zhao Y,Sui L,Wu P,Wang W,Wang Z,Yu Y,Hou Z,Tan G,Liu Q,Wang G

Wed Sep 01 00:00:00 EDT 2021

African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway.

Veterinary microbiology

Yang K,Huang Q,Wang R,Zeng Y,Cheng M,Xue Y,Shi C,Ye L,Yang W,Jiang Y,Wang J,Huang H,Cao X,Yang G,Wang C

Wed Dec 01 00:00:00 EST 2021

TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration.

Frontiers in immunology

Jiang Y,Chen S,Li Q,Liang J,Lin W,Li J,Liu Z,Wen M,Cao M,Hong J

Wed Jun 30 00:00:00 EDT 2021

TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration.

Frontiers in immunology

Jiang Y,Chen S,Li Q,Liang J,Lin W,Li J,Liu Z,Wen M,Cao M,Hong J

Wed Jun 30 00:00:00 EDT 2021

Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.

Journal of neuroinflammation

Peng Y,Zhuang J,Ying G,Zeng H,Zhou H,Cao Y,Chen H,Xu C,Fu X,Xu H,Li J,Cao S,Chen J,Gu C,Yan F,Chen G

Mon May 25 00:00:00 EDT 2020

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.

Protein & cell

Li M,Shu HB

Sat Aug 01 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: FLJ11330; NF-kappa-B-activating kinase; NF-kB-activating kinase; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; tbk

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Gene Aliases: FTDALS4; NAK; T2K; TBK1

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UniProt ID: (Human) Q9UHD2

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Entrez Gene ID: (Human) 29110

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Function(s)

nucleic acid binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding phosphoprotein binding non-receptor serine/threonine protein kinase protein modifying enzyme

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TBK1 Polyclonal Antibody

TBK1 Antibody (28397-1-AP) in IHC (P)

Product Details

28397-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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