Proteintech

TBX5 Polyclonal Antibody

TBX5 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

TBX5 Antibody (13178-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 13178-1-AP (TBX5 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

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Product Details

13178-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TBX5 Fusion Protein Ag3845 (1-328 aa encoded by BC027942)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MADADEGFG LAHTPLEPDA KDLPCDSKPE SALGAPSKSP SSPQAAFTQQ GMEGIKVFLH ERELWLKFHE VGTEMIITKA GRRMFPSYKV KVTGLNPKTK YILLMDIVPA DDHRYKFADN KWSVTGKAEP AMPGRLYVHP DSPATGAHWM RQLVSFQKLK LTNNHLDPFG HIILNSMHKY QPRLHIVKAD ENNGFGSKNT AFCTHVFPET AFIAVTSYQN HKITQLKIEN NPFAKGFRGS DDMELHRMSR MQSKEYPVVP RSTVRQKVAS NHSPFSSESR ALSTSSNLGS QYQCENGVSG PSQDLLPPPN PYPLPQEHSQ IYHCTKRKE (1-328 aa encoded by BC027942 )

Target Information

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Identification of a novel TBX5 c.755 + 1 G > A variant and related pathogenesis in a family with Holt-Oram syndrome.

American journal of medical genetics. Part A

Wang DG,Dong XS,Xiong Y,Li ZM,Xie YJ,Liang SH,Huang TH

Sat Jan 01 00:00:00 EST 2022

Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes.

The European respiratory journal

Du M,Jiang H,Liu H,Zhao X,Zhou Y,Zhou F,Piao C,Xu G,Ma F,Wang J,Perros F,Morrell NW,Gu H,Yang J

Fri Jul 01 00:00:00 EDT 2022

A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells.

iScience

Ghazizadeh Z,Zhu J,Fattahi F,Tang A,Sun X,Amin S,Tsai SY,Khalaj M,Zhou T,Samuel RM,Zhang T,Ortega FA,Gordillo M,Moroziewicz D,Paull D,Noggle SA,Xiang JZ,Studer L,Christini DJ,Pitt GS,Evans T,Chen S

Fri Apr 15 00:00:00 EDT 2022

Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling.

Environmental science & technology

Ren Z,Ku T,Gao Y,Yang X,Meng L,Liu QS,Liang J,Xu H,Liao C,Zhou Q,Faiola F,Jiang G

Tue Jun 21 00:00:00 EDT 2022

Functional and Adaptive Significance of Promoter Mutations That Affect Divergent Myocardial Expressions of TRIM72 in Primates.

Molecular biology and evolution

Feng Y,Xu H,Liu J,Xie N,Gao L,He Y,Yao Y,Lv F,Zhang Y,Lu J,Zhang W,Li CY,Hu X,Yang Z,Xiao RP

Fri Jun 25 00:00:00 EDT 2021

Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures.

Stem cell reports

Kurotsu S,Sadahiro T,Fujita R,Tani H,Yamakawa H,Tamura F,Isomi M,Kojima H,Yamada Y,Abe Y,Murakata Y,Akiyama T,Muraoka N,Harada I,Suzuki T,Fukuda K,Ieda M

Tue Sep 08 00:00:00 EDT 2020

Ensuring expression of four core cardiogenic transcription factors enhances cardiac reprogramming.

Scientific reports

Zhang Z,Zhang AD,Kim LJ,Nam YJ

Wed Apr 24 00:00:00 EDT 2019

Stoichiometric optimization of Gata4, Hand2, Mef2c, and Tbx5 expression for contractile cardiomyocyte reprogramming.

Scientific reports

Zhang Z,Zhang W,Nam YJ

Fri Oct 18 00:00:00 EDT 2019

Placental P-glycoprotein inhibition enhances susceptibility to Di-(2-ethylhexyl)-phthalate induced cardiac malformations in mice: A possibly promising target for congenital heart defects prevention.

PloS one

Tang C,Luo C,Hua Y,Zhou K,Duan H,Ma F,Zhang Y,Li Y,Qiu D,Wang C

Mon Jan 13 00:00:00 EST 2020

The effect of maternal exposure to di-(2-ethylhexyl)-phthalate on fetal cardiac development in mice.

Journal of applied toxicology : JAT

Tang C,Deng Y,Duan H,Zhang Y,Li Y,Qiu D,Zhou K,Hua Y,Wang C

Fri Jun 01 00:00:00 EDT 2018

The effect of maternal exposure to di-(2-ethylhexyl)-phthalate on fetal cardiac development in mice.

Journal of applied toxicology : JAT

Tang C,Deng Y,Duan H,Zhang Y,Li Y,Qiu D,Zhou K,Hua Y,Wang C

Fri Jun 01 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: T-box protein 5; T-box transcription factor TBX5

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Gene Aliases: HOS; TBX5

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UniProt ID: (Human) Q99593, (Mouse) P70326, (Rat) Q5I2P1

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Entrez Gene ID: (Human) 6910, (Mouse) 21388, (Rat) 304514

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Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding sequence-specific DNA binding Rel homology transcription factor

Process(es)

morphogenesis of an epithelium bundle of His development atrioventricular valve morphogenesis endocardial cushion development cardiac left ventricle formation ventricular septum development transcription initiation from RNA polymerase II promoter cell-cell signaling pattern specification process heart development negative regulation of cell proliferation negative regulation of epithelial to mesenchymal transition lung development embryonic limb morphogenesis negative regulation of cell migration embryonic forelimb morphogenesis forelimb morphogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of cardioblast differentiation cardiac muscle cell differentiation pericardium development negative regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation transdifferentiation atrial septum morphogenesis cell migration involved in coronary vasculogenesis positive regulation of secondary heart field cardioblast proliferation regulation of execution phase of apoptosis ventricular cardiac muscle tissue development atrial septum development transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development apoptotic nuclear changes

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TBX5 Polyclonal Antibody

TBX5 Antibody (13178-1-AP) in ICC/IF

Product Details

13178-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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