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Product Details
PA5-102363
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TCF4(Accession P15884), corresponding to amino acid residues A41-L91.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2851770
Product Specific Information
Antibody detects endogenous levels of total TCF4.
Target Information
TCF4 is transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG')-a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Defects in this gene are a cause of Pitt-Hopkins syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHb19; Class A helix-loop-helix transcription factor ME2; Class B basic helix-loop-helix protein 19; E2 2; Immunoglobulin transcription factor 2; immunoglobulin transcription factor-2; ITF 2; ITF-2; MGC149723; MGC149724; MITF-2; R8f DNA-binding protein; RITF-2; SEF 2; SEF-2; SEF2 1; SEF2 1A; SEF2 1B; SL3-3 enhancer factor 2; TCF 4; TCF-4; Transcription factor 4; Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2); transcription factor 4, isoform C; transcription factor 4, isoform D; transcription factor 4, isoform E; transcription factor 4, isoform L; transcription factor 4, isoform M; transcription factor 4, isoform R
Gene Aliases: 5730422P05Rik; ASP-I2; BHLHB19; E2-2; E2.2; FECD3; ITF-2; ITF-2b; ITF2; ME2; MITF-2A; MITF-2B; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4; TCF4; TFE
UniProt ID: (Human) P15884, (Mouse) Q60722, (Rat) Q62655
Entrez Gene ID: (Human) 6925, (Mouse) 21413, (Rat) 84382
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, TFIIB-class binding
TFIIB-class transcription factor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein C-terminus binding
identical protein binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
E-box binding
chromatin binding
double-stranded DNA binding
transcription corepressor activity
protein dimerization activity
basic helix-loop-helix transcription factor
DNA-templated transcription, initiation
transcription initiation from RNA polymerase II promoter
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
protein-DNA complex assembly
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
nervous system development
cell differentiation
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