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TCOF1 Antibody (PA5-101158) in IHC (P)
Immunohistochemistry analysis of TCOF1 in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with TCOF1 polyclonal antibody (Product # PA5-101158) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-101158
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TCOF1(Accession Q13428), corresponding to amino acid residues G35-S85.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850602
Product Specific Information
Antibody detects endogenous levels of total TCOF1.
Target Information
Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: nucleolar trafficking phosphoprotein; Treacher Collins syndrome protein; Treacher Collins syndrome protein homolog; Treacher Collins-Franceschetti syndrome 1; Treacle protein
Gene Aliases: AA408847; AW209012; MFD1; TCOF1; TCS; TCS1; treacle
UniProt ID: (Human) Q13428, (Mouse) O08784
Entrez Gene ID: (Human) 6949, (Mouse) 21453
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