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Product Details
PA5-80101
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Tec (612-631aa FEDLLRTIDELVECEETFGR).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2747216
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
TEC is a non-receptor protein-tyrosine kinase containing a pleckstrin homology domain and is highly expressed in many hematopoietic cell lines. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytoplasmic tyrosine kinase, Dscr28C related; MGC126760; MGC126762; Tyrosine-protein kinase Tec
Gene Aliases: PSCTK4; TEC
UniProt ID: (Human) P42680, (Mouse) P24604
Entrez Gene ID: (Human) 7006, (Rat) 84492, (Mouse) 21682
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
phospholipid binding
metal ion binding
protein tyrosine kinase activity
nucleotide binding
protein kinase activity
lipid binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
adaptive immune response
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
integrin-mediated signaling pathway
regulation of platelet activation
peptidyl-tyrosine phosphorylation
cell differentiation
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
Fc-epsilon receptor signaling pathway
regulation of cell proliferation
tissue regeneration
innate immune response
positive regulation of peptidyl-tyrosine phosphorylation
B cell receptor signaling pathway
T cell receptor signaling pathway
immune system process
phosphorylation
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