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Product Details
22020-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TERF2 Fusion Protein Ag16798 (1-251 aa encoded by BC024890)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAGGGGSSD GSGRAAGRRA SRSSGRARRG RHEPGLGGPA ERGAGEARLE EAVNRWVLKF YFHEALRAFR GSRYGDFRQI RDIMQALLVR PLGKEHTVSR LLRVMQCLSR IEEGENLDCS FDMEAELTPL ESAINVLEMI KTEFTLTEAV VESSRKLVKE AAVIICIKNK EFEKASKILK KHMSKDPTTQ KLRNDLLNII REKNLAHPVI QNFSYETFQQ KMLRFLESHL DDAEPYLLTV RLGPSPITMV CP (1-251 aa encoded by BC024890)
Target Information
TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Telomeric DNA-binding protein; telomeric repeat binding protein 2; Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2
Gene Aliases: TERF2; TRBF2; TRF2
UniProt ID: (Human) Q15554, (Mouse) O35144
Entrez Gene ID: (Human) 7014, (Rat) 361403, (Mouse) 21750
telomere maintenance
in utero embryonic development
positive regulation of gene expression
negative regulation of gene expression
obsolete telomere maintenance via telomere shortening
telomere capping
telomeric loop formation
protection from non-homologous end joining at telomere
negative regulation of telomere maintenance
positive regulation of telomere maintenance
positive regulation of nitric-oxide synthase activity
protein localization to chromosome, telomeric region
negative regulation of beta-galactosidase activity
negative regulation of cellular senescence
cell cycle
regulation of telomere maintenance
telomere maintenance via telomerase
negative regulation of telomere maintenance via recombination
regulation of telomere maintenance via telomerase
negative regulation of telomere maintenance via semi-conservative replication
cellular senescence
negative regulation of telomere single strand break repair
negative regulation of telomere capping
negative regulation of t-circle formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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