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Product Details
PA5-142789
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence TDGLCFVSVTETTD.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933432
Product Specific Information
Additional Information: This antibody is expected to recognize both reported isoforms (NP_004603.1; NP_001124388.1). The immunizing peptide represents part of a potential extracellular domain.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
This antibody is not recommended for ICC/IF.
Target Information
TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type II-like kinase, 53kDa; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; mutant transforming growth factor beta receptor I; ser; Serine/threonine-protein kinase receptor R4; SKR4; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; TGFR1; Transfor; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I; Transforming growth factor-beta receptor type I
Gene Aliases: AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TGFBR1; TGFR-1
UniProt ID: (Human) P36897, (Rat) P80204
Entrez Gene ID: (Human) 7046, (Rat) 29591
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor activity, type I
receptor signaling protein activity
type II transforming growth factor beta receptor binding
protein binding
ATP binding
growth factor binding
SMAD binding
metal ion binding
transforming growth factor beta binding
I-SMAD binding
ubiquitin protein ligase binding
protein complex binding
protein heterodimerization activity
serine/threonine protein kinase receptor
activation of MAPKK activity
skeletal system development
angiogenesis
in utero embryonic development
kidney development
blastocyst development
epithelial to mesenchymal transition
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
lens development in camera-type eye
ventricular trabecula myocardium morphogenesis
ventricular compact myocardium morphogenesis
proepicardium development
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
cell cycle arrest
signal transduction
transforming growth factor beta receptor signaling pathway
heart development
positive regulation of cell proliferation
germ cell migration
male gonad development
post-embryonic development
anterior/posterior pattern specification
regulation of epithelial to mesenchymal transition
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
collagen fibril organization
positive regulation of cell growth
positive regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of protein ubiquitination
negative regulation of chondrocyte differentiation
activin receptor signaling pathway
intracellular signal transduction
wound healing
endothelial cell activation
extracellular structure organization
regulation of protein binding
endothelial cell migration
positive regulation of transcription, DNA-templated
thymus development
neuron fate commitment
embryonic cranial skeleton morphogenesis
skeletal system morphogenesis
mesenchymal cell differentiation
artery morphogenesis
cell motility
positive regulation of cellular component movement
positive regulation of filopodium assembly
positive regulation of stress fiber assembly
positive regulation of protein kinase B signaling
parathyroid gland development
palate development
pharyngeal system development
regulation of cardiac muscle cell proliferation
cardiac epithelial to mesenchymal transition
pathway-restricted SMAD protein phosphorylation
positive regulation of SMAD protein import into nucleus
ventricular septum morphogenesis
coronary artery morphogenesis
response to cholesterol
cellular response to transforming growth factor beta stimulus
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of occluding junction disassembly
positive regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
response to hypoxia
transmembrane receptor protein serine/threonine kinase signaling pathway
embryo implantation
aging
response to toxic substance
regulation of gene expression
positive regulation of gene expression
response to organic cyclic compound
lung development
organ regeneration
response to prostaglandin E
regulation of growth
negative regulation of apoptotic process
response to estrogen
negative regulation of endothelial cell differentiation
protein autophosphorylation
digestive tract development
response to electrical stimulus
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