Invitrogen

TNFAIP3 Recombinant Rabbit Monoclonal Antibody (ARC0355)

View all (26) TNFAIP3 antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-35277

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0355

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 450-550 of human TNFAIP3 (P21580)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.95 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849179

Product Specific Information

Immunogen sequence: PEESTGGPHS APPTAPSPFL FSETTAMKCR SPGCPFTLNV QHNGFCERCH NARQLHASHA PDHTRHLDPG KCQACLQDVT RTFNGICSTC FKRTTAEASS S

Target Information

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-a, inhibiting NF-kappa-B-dependent gene expression, and protecting cells from TNF-a-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTU domain-containing protein 7C; Putative DNA-binding protein A20; RP11-356I2.3; TNF alpha-induced protein 3; TNFAIP3 (A20); Tumor necrosis factor alpha-induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; tumor necrosis factor, alpha-induced protein 3; Zinc finger protein A20

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Gene Aliases: A20; AISBL; OTUD7C; TNFA1P2; TNFAIP3

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UniProt ID: (Human) P21580

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Entrez Gene ID: (Human) 7128

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Function(s)
protease binding DNA binding ubiquitin-protein transferase activity thiol-dependent ubiquitin-specific protease activity protein binding zinc ion binding ligase activity kinase binding ubiquitin binding protein self-association K63-linked polyubiquitin binding cysteine protease
Process(es)
B-1 B cell homeostasis response to molecule of bacterial origin regulation of germinal center formation negative regulation of chronic inflammatory response apoptotic process inflammatory response regulation of tumor necrosis factor-mediated signaling pathway protein deubiquitination negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity negative regulation of type I interferon production response to muramyl dipeptide negative regulation of interleukin-1 beta production negative regulation of interleukin-2 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 3 signaling pathway negative regulation of toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 5 signaling pathway protein K11-linked deubiquitination negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of bone resorption negative regulation of innate immune response negative regulation of smooth muscle cell proliferation regulation of defense response to virus by host regulation of inflammatory response negative regulation of inflammatory response negative regulation of B cell activation protein oligomerization regulation of vascular wound healing cellular response to hydrogen peroxide nucleotide-binding oligomerization domain containing signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway protein K63-linked deubiquitination protein K48-linked ubiquitination protein K48-linked deubiquitination cellular response to lipopolysaccharide protein deubiquitination involved in ubiquitin-dependent protein catabolic process tolerance induction to lipopolysaccharide establishment of protein localization to vacuole negative regulation of osteoclast proliferation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of cellular protein catabolic process positive regulation of hepatocyte proliferation negative regulation of CD40 signaling pathway negative regulation of endothelial cell apoptotic process
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