Proteintech

TOLLIP Polyclonal Antibody

TOLLIP Antibody in Immunocytochemistry (ICC/IF)

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TOLLIP Antibody (11315-1-AP) in ICC/IF

Immunofluorescent analysis of PC-3 cells using 11315-1-AP (TOLLIP antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TOLLIP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

11315-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TOLLIP Fusion Protein Ag1864 (1-274 aa encoded by BC012057)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATTVSTQR GPVYIGELPQ DFLRITPTQQ QRQVQLDAQA AQQLQYGGAV GTVGRLNITV VQAKLAKNYG MTRMDPYCRL RLGYAVYETP TAHNGAKNPR WNKVIHCTVP PGVDSFYLEI FDERAFSMDD RIAWTHITIP ESLRQGKVED KWYSLSGRQG DDKEGMINLV MSYALLPAAM VMPPQPVVLM PTVYQQGVGY VPITGMPAVC SPGMVPVALP PAAVNAQPRC SEEDLKAIQD MFPNMDQEVI RSVLEAQRGN KDAAINSLLQ MGEEP (1-274 aa encoded by BC012057)

Target Information

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.

Science advances

Hu Z,Xie Y,Lu J,Yang J,Zhang J,Jiang H,Li H,Zhang Y,Wu D,Zeng K,Bai X,Yu X

Fri Jun 23 00:00:00 EDT 2023

Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.

Autophagy

Ma Z,Bai J,Jiang C,Zhu H,Liu D,Pan M,Wang X,Pi J,Jiang P,Liu X

Mon May 01 00:00:00 EDT 2023

Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.

Autophagy

Ma Z,Bai J,Jiang C,Zhu H,Liu D,Pan M,Wang X,Pi J,Jiang P,Liu X

Mon May 01 00:00:00 EDT 2023

TOLLIP-mediated autophagic degradation pathway links the VCP-TMEM63A-DERL1 signaling axis to triple-negative breast cancer progression.

Autophagy

Zhang TM,Liao L,Yang SY,Huang MY,Zhang YL,Deng L,Hu SY,Yang F,Zhang FL,Shao ZM,Li DQ

Wed Mar 01 00:00:00 EST 2023

African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic Degradation.

Journal of virology

Cheng M,Kanyema MM,Sun Y,Zhao W,Lu Y,Wang J,Li X,Shi C,Wang J,Wang N,Yang W,Jiang Y,Huang H,Yang G,Zeng Y,Wang C,Cao X

Tue Feb 28 00:00:00 EST 2023

Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats.

Gut microbes

Sargin P,Roethle MF,Jia S,Pant T,Ciecko AE,Atkinson SN,Salzman NH,Teng RJ,Chen YG,Cabrera SM,Hessner MJ

Fri Oct 21 00:00:00 EDT 2022

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

Nature communications

Jin S,He X,Ma L,Zhuang Z,Wang Y,Lin M,Cai S,Wei L,Wang Z,Zhao Z,Wu Y,Sun L,Li C,Xie W,Zhao Y,Songyang Z,Peng K,Zhao J,Cui J

Sat Sep 03 00:00:00 EDT 2022

The Globular C1q Receptor Is Required for Epidermal Growth Factor Receptor Signaling during Candida albicans Infection.

mBio

Phan QT,Lin J,Solis NV,Eng M,Swidergall M,Wang F,Li S,Gaffen SL,Chou TF,Filler SG

Tue Dec 21 00:00:00 EST 2021

Bioinformatics

Protein Aliases: adapter protein; FLJ33531; Toll-interacting protein; tollip {ECO:0000312|EMBL:AAI33068.1}

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Gene Aliases: 4930403G24Rik; 4931428G15Rik; IL-1RAcPIP; TOLLIP

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UniProt ID: (Human) Q9H0E2, (Rat) A2RUW1, (Mouse) Q9QZ06

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Entrez Gene ID: (Human) 54472, (Rat) 361677, (Mouse) 54473

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Function(s)

signal transducer activity interleukin-1, Type I receptor binding protein binding kinase binding ubiquitin conjugating enzyme binding ubiquitin protein ligase binding SUMO binding Toll-like receptor binding

Process(es)

autophagy inflammatory response signal transduction phosphorylation epithelial cell differentiation positive regulation of protein sumoylation protein localization to endosome innate immune response cell-cell signaling intracellular signal transduction leukocyte activation immune system process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TOLLIP Polyclonal Antibody

TOLLIP Antibody (11315-1-AP) in ICC/IF

Product Details

11315-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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