Invitrogen

TRAF2 Recombinant Rabbit Monoclonal Antibody (3S2A8)

View all (33) TRAF2 antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-51192

Applications
Tested Dilution
Publications

Western Blot (WB)

1:10,000-1:60,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunoprecipitation (IP)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

3S2A8

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 190-350 of human TRAF2 (NP_066961.2).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3093784

Product Specific Information

Immunogen sequence: DGCGKKKIPR EKFQDHVKTC GKCRVPCRFH AIGCLETVEG EKQQEHEVQW LREHLAMLLS SVLEAKPLLG DQSHAGSELL QRCESLEKKT ATFENIVCVL NREVERVAMT AEACSRQHRL DQDKIEALSS KVQQLERSIG LKDLAMADLE QKVLEMEAST Y

Target Information

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase TRAF2; OTTHUMP00000064745; RING-type E3 ubiquitin transferase TRAF2; TNF receptor-associated factor 2; tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3

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Gene Aliases: AI325259; MGC:45012; TRAF2; TRAP; TRAP3

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UniProt ID: (Human) Q12933, (Mouse) P39429

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Entrez Gene ID: (Human) 7186, (Mouse) 22030, (Rat) 311786

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Function(s)
ubiquitin-protein transferase activity signal transducer activity tumor necrosis factor receptor binding CD40 receptor binding protein binding zinc ion binding ligase activity enzyme binding protein kinase binding protein phosphatase binding mitogen-activated protein kinase kinase kinase binding ubiquitin protein ligase binding thioesterase binding protein complex binding identical protein binding sphingolipid binding receptor binding lipid binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity scaffold/adaptor protein
Process(es)
positive regulation of T cell cytokine production protein complex assembly activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction I-kappaB kinase/NF-kappaB signaling activation of NF-kappaB-inducing kinase activity regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death protein catabolic process positive regulation of interleukin-2 production tumor necrosis factor-mediated signaling pathway negative regulation of glial cell apoptotic process response to endoplasmic reticulum stress regulation of apoptotic process positive regulation of JUN kinase activity cellular protein complex assembly positive regulation of T cell activation regulation of immunoglobulin secretion positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein heterooligomerization protein autoubiquitination intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress protein homotrimerization protein K63-linked ubiquitination death-inducing signaling complex assembly cellular response to nitric oxide positive regulation of protein homodimerization activity activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway programmed necrotic cell death negative regulation of neuron death regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of I-kappaB phosphorylation positive regulation of extrinsic apoptotic signaling pathway apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of JNK cascade
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