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TRPML3 (Mucolipin 3) Antibody (ACC-083-200UL) in IHC
Expression of Mucolipin 3 in mouse brain stem - Immunohistochemical staining of TRPML3 in mouse brain stem using Anti-TRPML3 (Mucolipin 3) Antibody (#ACC-083). A. TRPML3 (green) appears in neurons (arrows) in the area of the dorsal cochlear nucleus. B. Staining of the same section with mouse Anti-parvalbumin (red) reveals that the TRPML3 appears in a subset of neurons in this nucleus. DAPI is used as the co... View More
Product Details
ACC-083-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CKDLPNSGKYRLEDD, corresponding to amino acid residues 528-542 of mouse TRPML3, Intracellular, C-terminus (cytoplasmic)
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Expressed in the cochlea; particularly in the inner and outer hair cells. Defects in Mcoln3 are the cause of the varitin-waddler (Va) phenotype. Classical Va mice exhibit early-onset hearing loss, vestibular defects, pigmentation abnormalities and perinatal lethality. The phenotype varitin-waddler Jackcon (Va-J), which arose in a cross segregating for Va, is similar but less severe. Belongs to the transient receptor family, polycystin subfamily.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ11006; FLJ36629; MCLN3; Mcoln3 mucolipin 3; MGC124245; MGC124246; MGC71509; Mucolipin-3; Transient receptor potential channel mucolipin 3; TRPML3; varitint-waddler
Gene Aliases: 6720490O21Rik; MCOLN3; TRP-ML3; TRPML3; Va
UniProt ID: (Human) Q8TDD5, (Mouse) Q8R4F0
Entrez Gene ID: (Human) 55283, (Rat) 308022, (Mouse) 171166
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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