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Product Details
PA5-86070
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to amino acids 1-50 of Human TWIST1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2802871
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-HLH DNA binding protein; bHLHa38; charlie chaplin; Class A basic helix-loop-helix protein 38; H-twist; M-twist; p ACS3; Pluridigite; polydactyly EMS; Skam10Jus; twist basic helix-loop-helix transcription factor 1; twist gene homolog 1; twist homolog 1; TWIST homolog of drosophila; Twist-related protein 1
Gene Aliases:
AA960487; ACS3; BHLHA38; BPES2; BPES3; CRS; CRS1; CSO; M-Twist; Pde; pdt; SCS; Ska10; Ska
UniProt ID: (Human) Q15672, (Mouse) P26687
Entrez Gene ID: (Human) 7291, (Mouse) 22160
RNA polymerase II transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein domain specific binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
E-box binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein dimerization activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
ossification
osteoblast differentiation
in utero embryonic development
neuron migration
neural tube closure
aortic valve morphogenesis
mitral valve morphogenesis
endocardial cushion morphogenesis
cardiac neural crest cell migration involved in outflow tract morphogenesis
transcription, DNA-templated
muscle organ development
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
negative regulation of phosphatidylinositol 3-kinase signaling
regulation of bone mineralization
positive regulation of fatty acid beta-oxidation
negative regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor production
negative regulation of histone phosphorylation
negative regulation of histone acetylation
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
negative regulation of peroxisome proliferator activated receptor signaling pathway
outer ear morphogenesis
odontogenesis
embryonic digit morphogenesis
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
negative regulation of skeletal muscle tissue development
embryonic cranial skeleton morphogenesis
positive regulation of epithelial cell proliferation
palate development
cranial suture morphogenesis
embryonic camera-type eye formation
eyelid development in camera-type eye
cellular response to growth factor stimulus
cellular response to hypoxia
positive regulation of monocyte chemotactic protein-1 production
positive regulation of DNA-templated transcription, initiation
positive regulation of cell motility
negative regulation of oxidative phosphorylation uncoupler activity
positive regulation of transcription regulatory region DNA binding
negative regulation of cellular senescence
positive regulation of interleukin-6 secretion
negative regulation of double-strand break repair
cell proliferation involved in heart valve development
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
cell differentiation
embryonic limb morphogenesis
hindlimb morphogenesis
negative regulation of molecular function
negative regulation of cell differentiation
negative regulation of striated muscle tissue development
embryonic skeletal system morphogenesis
cardiac neural crest cell development involved in outflow tract morphogenesis
Performance Guarantee
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