Proteintech

Thrombospondin 1 Polyclonal Antibody

Thrombospondin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Thrombospondin 1 Antibody (18304-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using (Product # 18304-1-AP) (Thrombospondin 1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Thrombospondin 1 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

18304-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 22 publications 22 publications

Immunohistochemistry (IHC)

Assay-dependent

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Transplantation of Human Amniotic Mesenchymal Stem Cells Up-Regulates Angiogenic Factor Expression to Attenuate Diabetic Kidney Disease in Rats.

Diabetes, metabolic syndrome and obesity : targets and therapy

Ni Y,Chen Y,Jiang X,Pu T,Zhang L,Li S,Hu L,Bai B,Hu T,Yu L,Yang Y

Wed Feb 15 00:00:00 EST 2023

Transplantation of Human Amniotic Mesenchymal Stem Cells Up-Regulates Angiogenic Factor Expression to Attenuate Diabetic Kidney Disease in Rats.

Diabetes, metabolic syndrome and obesity : targets and therapy

Ni Y,Chen Y,Jiang X,Pu T,Zhang L,Li S,Hu L,Bai B,Hu T,Yu L,Yang Y

Wed Feb 15 00:00:00 EST 2023

Lactic acidosis induces metabolic and phenotypic reprogramming in cholangiocarcinoma cells via the upregulation of thrombospondin-1.

Cancer science

Thamrongwaranggoon U,Kuribayashi K,Araki H,Hino Y,Koga T,Seubwai W,Wongkham S,Nakao M,Hino S

Sat Apr 01 00:00:00 EDT 2023

Lactic acidosis induces metabolic and phenotypic reprogramming in cholangiocarcinoma cells via the upregulation of thrombospondin-1.

Cancer science

Thamrongwaranggoon U,Kuribayashi K,Araki H,Hino Y,Koga T,Seubwai W,Wongkham S,Nakao M,Hino S

Sat Apr 01 00:00:00 EDT 2023

Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage.

Journal of neurochemistry

Qiu X,Tao Q,Zhang L,Kuang C,Xie Y,Zhang L,Yin S,Peng J,Jiang Y

Wed Mar 01 00:00:00 EST 2023

MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis.

Cancer research and treatment

Yang Y,Qiu R,Weng Q,Xu Z,Song J,Zhao S,Meng M,Zhang D,Kong C,Wang H,Xu M,Zhao Z,Ji J

Sat Jul 01 00:00:00 EDT 2023

Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries.

European journal of pharmacology

Zhou W,Wang C,Zhang B,Gou S

Wed Jul 05 00:00:00 EDT 2023

Yth m⁶A RNA-Binding Protein 1 Regulates Osteogenesis of MC3T3-E1 Cells under Hypoxia via Translational Control of Thrombospondin-1.

International journal of molecular sciences

Shi D,Liu X,Li X,Li T,Liu J,Wu L

Mon Jan 16 00:00:00 EST 2023

Yth m⁶A RNA-Binding Protein 1 Regulates Osteogenesis of MC3T3-E1 Cells under Hypoxia via Translational Control of Thrombospondin-1.

International journal of molecular sciences

Shi D,Liu X,Li X,Li T,Liu J,Wu L

Mon Jan 16 00:00:00 EST 2023

PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.

iScience

Peng Z,Tan X,Xie L,Li Z,Zhou S,Li Y

Fri Jan 20 00:00:00 EST 2023

PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.

iScience

Peng Z,Tan X,Xie L,Li Z,Zhou S,Li Y

Fri Jan 20 00:00:00 EST 2023

PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.

iScience

Peng Z,Tan X,Xie L,Li Z,Zhou S,Li Y

Fri Jan 20 00:00:00 EST 2023

PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.

iScience

Peng Z,Tan X,Xie L,Li Z,Zhou S,Li Y

Fri Jan 20 00:00:00 EST 2023

CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology

Singla B,Aithbathula RV,Pervaiz N,Kathuria I,Swanson M,Ekuban FA,Ahn W,Park F,Gyamfi M,Cherian-Shaw M,Singh UP,Kumar S

Sat Jul 01 00:00:00 EDT 2023

CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology

Singla B,Aithbathula RV,Pervaiz N,Kathuria I,Swanson M,Ekuban FA,Ahn W,Park F,Gyamfi M,Cherian-Shaw M,Singh UP,Kumar S

Sat Jul 01 00:00:00 EDT 2023

CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology

Singla B,Aithbathula RV,Pervaiz N,Kathuria I,Swanson M,Ekuban FA,Ahn W,Park F,Gyamfi M,Cherian-Shaw M,Singh UP,Kumar S

Sat Jul 01 00:00:00 EDT 2023

CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology

Singla B,Aithbathula RV,Pervaiz N,Kathuria I,Swanson M,Ekuban FA,Ahn W,Park F,Gyamfi M,Cherian-Shaw M,Singh UP,Kumar S

Sat Jul 01 00:00:00 EDT 2023

Circ_0047339 promotes the activation of fibroblasts and affects the development of urethral stricture by targeting the miR-4691-5p/TSP-1 axis.

Scientific reports

Ding K,Li D,Zhang R,Zuo M

Tue Aug 30 00:00:00 EDT 2022

Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.

Translational oncology

Liu X,Li N,Zhang C,Wu X,Zhang S,Dong G,Liu G

Sun May 01 00:00:00 EDT 2022

Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.

Translational oncology

Liu X,Li N,Zhang C,Wu X,Zhang S,Dong G,Liu G

Sun May 01 00:00:00 EDT 2022

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation.

Cancer cell

Xiao Y,Cong M,Li J,He D,Wu Q,Tian P,Wang Y,Yang S,Liang C,Liang Y,Wen J,Liu Y,Luo W,Lv X,He Y,Cheng DD,Zhou T,Zhao W,Zhang P,Zhang X,Xiao Y,Qian Y,Wang H,Gao Q,Yang QC,Yang Q,Hu G

Mon Mar 08 00:00:00 EST 2021

miR-19a-3p Promotes Tumor-Relevant Behaviors in Bladder Urothelial Carcinoma via Targeting THBS1.

Computational and mathematical methods in medicine

Xu G,Li J,Yu L

Wed Jan 12 00:00:00 EST 2022

The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets.

Nature communications

Nording H,Baron L,Haberthür D,Emschermann F,Mezger M,Sauter M,Sauter R,Patzelt J,Knoepp K,Nording A,Meusel M,Meyer-Saraei R,Hlushchuk R,Sedding D,Borst O,Eitel I,Karsten CM,Feil R,Pichler B,Erdmann J,Verschoor A,Chavakis E,Chavakis T,von Hundelshausen P,Köhl J,Gawaz M,Langer HF

Mon Jun 07 00:00:00 EDT 2021

High Level of Staufen1 Expression Confers Longer Recurrence Free Survival to Non-Small Cell Lung Cancer Patients by Promoting THBS1 mRNA Degradation.

International journal of molecular sciences

Bonnet-Magnaval F,Diallo LH,Brunchault V,Laugero N,Morfoisse F,David F,Roussel E,Nougue M,Zamora A,Marchaud E,Tatin F,Prats AC,Garmy-Susini B,DesGroseillers L,Lacazette E

Sat Dec 25 00:00:00 EST 2021

Cross-talk between synovial fibroblasts and chondrocytes in condylar hyperplasia: an in vitro pilot study.

Oral surgery, oral medicine, oral pathology and oral radiology

Guo H,Li H,Feng Y,Ke J,Fang W,Li C,Long X

Sat May 01 00:00:00 EDT 2021

tRNA-Derived Fragment tRF-17-79MP9PP Attenuates Cell Invasion and Migration via THBS1/TGF-β1/Smad3 Axis in Breast Cancer.

Frontiers in oncology

Mo D,He F,Zheng J,Chen H,Tang L,Yan F

Fri Apr 30 00:00:00 EDT 2021

The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype.

Molecular and cellular endocrinology

Jing Y,Gao B,Han Z,Xia L,Xin S

Fri Aug 20 00:00:00 EDT 2021

MiR-18a-5p acts as a novel serum biomarker for venous malformation and promotes angiogenesis by regulating the thrombospondin-1/P53 signaling axis.

American journal of translational research

Zhang L,Wang D,Wang Z,Li X,Xia W,Han Y,Su L,Fan X

Thu Nov 18 00:00:00 EST 2021

MiR-18a-5p acts as a novel serum biomarker for venous malformation and promotes angiogenesis by regulating the thrombospondin-1/P53 signaling axis.

American journal of translational research

Zhang L,Wang D,Wang Z,Li X,Xia W,Han Y,Su L,Fan X

Thu Nov 18 00:00:00 EST 2021

MiR-18a-5p acts as a novel serum biomarker for venous malformation and promotes angiogenesis by regulating the thrombospondin-1/P53 signaling axis.

American journal of translational research

Zhang L,Wang D,Wang Z,Li X,Xia W,Han Y,Su L,Fan X

Thu Nov 18 00:00:00 EST 2021

MiR-18a-5p acts as a novel serum biomarker for venous malformation and promotes angiogenesis by regulating the thrombospondin-1/P53 signaling axis.

American journal of translational research

Zhang L,Wang D,Wang Z,Li X,Xia W,Han Y,Su L,Fan X

Thu Nov 18 00:00:00 EST 2021

Serum Exosomal Proteins F9 and TSP-1 as Potential Diagnostic Biomarkers for Newly Diagnosed Epilepsy.

Frontiers in neuroscience

Lin Z,Gu Y,Zhou R,Wang M,Guo Y,Chen Y,Ma J,Xiao F,Wang X,Tian X

Mon Sep 28 00:00:00 EDT 2020

Discovery of small extracellular vesicle proteins from human serum for liver cirrhosis and liver cancer.

Biochimie

Uzzaman A,Zhang X,Qiao Z,Zhan H,Sohail A,Wahid A,Shang Z,Guan X,Cao CX,Xiao H

Thu Oct 01 00:00:00 EDT 2020

Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.

Molecular medicine reports

Zhao J,Meng M,Zhang J,Li L,Zhu X,Zhang L,Wang C,Gao M

Mon Apr 01 00:00:00 EDT 2019

Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.

Molecular medicine reports

Zhao J,Meng M,Zhang J,Li L,Zhu X,Zhang L,Wang C,Gao M

Mon Apr 01 00:00:00 EDT 2019

Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction.

Nature communications

Tang J,Shen Y,Chen G,Wan Q,Wang K,Zhang J,Qin J,Liu G,Zuo S,Tao B,Yu Y,Wang J,Lazarus M,Yu Y

Fri Mar 03 00:00:00 EST 2017

Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction.

Nature communications

Tang J,Shen Y,Chen G,Wan Q,Wang K,Zhang J,Qin J,Liu G,Zuo S,Tao B,Yu Y,Wang J,Lazarus M,Yu Y

Fri Mar 03 00:00:00 EST 2017

Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-κB Signaling Pathway.

Inflammation

Xing T,Wang Y,Ding WJ,Li YL,Hu XD,Wang C,Ding A,Shen JL

Sun Oct 01 00:00:00 EDT 2017

IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Xu J,Cai H,Meng Q,Li Y,Chen G,Fang W,Long X

Thu Sep 01 00:00:00 EDT 2016

IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Xu J,Cai H,Meng Q,Li Y,Chen G,Fang W,Long X

Thu Sep 01 00:00:00 EDT 2016

Novel circulating peptide biomarkers for esophageal squamous cell carcinoma revealed by a magnetic bead-based MALDI-TOFMS assay.

Oncotarget

Jia K,Li W,Wang F,Qu H,Qiao Y,Zhou L,Sun Y,Ma Q,Zhao X

Tue Apr 26 00:00:00 EDT 2016

Novel circulating peptide biomarkers for esophageal squamous cell carcinoma revealed by a magnetic bead-based MALDI-TOFMS assay.

Oncotarget

Jia K,Li W,Wang F,Qu H,Qiao Y,Zhou L,Sun Y,Ma Q,Zhao X

Tue Apr 26 00:00:00 EDT 2016

Upregulation of proangiogenic factors expression in the synovium of temporomandibular joint condylar hyperplasia.

Oral surgery, oral medicine, oral pathology and oral radiology

Guo H,Fang W,Chen G,Xu J,Li C,Feng Y,Li Y,Long X

Fri Apr 01 00:00:00 EDT 2016

Upregulation of proangiogenic factors expression in the synovium of temporomandibular joint condylar hyperplasia.

Oral surgery, oral medicine, oral pathology and oral radiology

Guo H,Fang W,Chen G,Xu J,Li C,Feng Y,Li Y,Long X

Fri Apr 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: Glycoprotein G; Thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1

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Gene Aliases: tbsp1; THBS; THBS-1; THBS1; TSP; TSP-1; TSP1

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UniProt ID: (Human) P07996

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Entrez Gene ID: (Human) 7057, (Rat) 445442, (Mouse) 21825

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Function(s)

phosphatidylserine binding glycoprotein binding fibronectin binding integrin binding calcium ion binding protein binding heparin binding fibroblast growth factor binding low-density lipoprotein particle binding identical protein binding laminin binding proteoglycan binding transforming growth factor beta binding fibrinogen binding collagen V binding extracellular matrix binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Thrombospondin 1 Polyclonal Antibody

Thrombospondin 1 Antibody (18304-1-AP) in IHC (P)

Product Details

18304-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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