Product References
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy.
Nature communications
Vanhoutte D,Schips TG,Vo A,Grimes KM,Baldwin TA,Brody MJ,Accornero F,Sargent MA,Molkentin JD
Published figure using Thrombospondin 1 monoclonal antibody (Product # MA5-13395) in Immunoprecipitation
Thu Jun 24 00:00:00 EDT 2021
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy.
Nature communications
Vanhoutte D,Schips TG,Vo A,Grimes KM,Baldwin TA,Brody MJ,Accornero F,Sargent MA,Molkentin JD
Published figure using Thrombospondin 1 monoclonal antibody (Product # MA5-13395) in Immunoprecipitation
Thu Jun 24 00:00:00 EDT 2021
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy.
Nature communications
Vanhoutte D,Schips TG,Vo A,Grimes KM,Baldwin TA,Brody MJ,Accornero F,Sargent MA,Molkentin JD
Published figure using Thrombospondin 1 monoclonal antibody (Product # MA5-13395) in Immunoprecipitation
Thu Jun 24 00:00:00 EDT 2021
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta.
eLife
Engelbrecht E,Levesque MV,He L,Vanlandewijck M,Nitzsche A,Niazi H,Kuo A,Singh SA,Aikawa M,Holton K,Proia RL,Kono M,Pu WT,Camerer E,Betsholtz C,Hla T
Published figure using Thrombospondin 1 monoclonal antibody (Product # MA5-13395) in Immunohistochemistry
Mon Feb 24 00:00:00 EST 2020
Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress.
Molecular and cellular biology
Zhao Y,Wang S,Sorenson CM,Teixeira L,Dubielzig RR,Peters DM,Conway SJ,Jefcoate CR,Sheibani N
MA5-13395 was used in western blot to study the role of oxidative stress in the mechanism by which Cyp1b1 mediates regulation of the trabecular meshwork by periostin
Fri Nov 01 00:00:00 EDT 2013
Inflammatory cytokine-specific alterations in retinal endothelial cell function.
Microvascular research
Palenski TL,Sorenson CM,Sheibani N
MA5-13395 was used in western blot to study the effects of the inflammatory mediators TNF-alpha and IL-1beta on the function of retinal endothelial cells and the implications for diabetic retinopathy
Sun Sep 01 00:00:00 EDT 2013
Long-term gene therapy with thrombospondin 2 inhibits TGF-β activation, inflammation and angiogenesis in chronic allograft nephropathy.
PloS one
Daniel C,Vogelbacher R,Stief A,Grigo C,Hugo C
MA5-13395 was used in immunohistochemistry to study TGF-beta activation, inflammation and angiogenesis following long-term thrombospondin-2 gene therapy in a model of chronic allograft nephropathy
Mon Mar 02 00:00:00 EST 2015
A histone deacetylase inhibitory prodrug - butyroyloxymethyl diethyl phosphate - protects the heart and cardiomyocytes against ischemia injury.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Kessler-Icekson G,Hochhauser E,Sinai T,Kremer A,Dick J,Tarasenko N,Nudelman V,Schlesinger H,Abraham S,Nudelman A,Rephaeli A
MA5-13395 was used in western blot to study the protective effects of a pro-drug histone deacetylase inhibitor against ischemia injury in heart and cardiomyocytes
Wed Apr 11 00:00:00 EDT 2012
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment.
American journal of physiology. Renal physiology
Sheibani N,Morrison ME,Gurel Z,Park S,Sorenson CM
MA5-13395 was used in western blot to study the differential effects of BIM deficiency on kidney endothelial and epithelial cells
Sun Apr 01 00:00:00 EDT 2012
The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity.
Investigational new drugs
Tarasenko N,Kessler-Icekson G,Boer P,Inbal A,Schlesinger H,Phillips DR,Cutts SM,Nudelman A,Rephaeli A
MA5-13395 was used in western blot to study the effect of a HDAC inhibitor on the toxicity of anti-cancer agents in normal and in cancer cells
Wed Feb 01 00:00:00 EST 2012
Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis.
PloS one
Martin-Manso G,Navarathna DH,Galli S,Soto-Pantoja DR,Kuznetsova SA,Tsokos M,Roberts DD
MA5-13395 was used in ELISA to study the effect of thrombospondin-1 in the immune response to Canida albicans infection and its role in the pathogenesis of disseminated candidiasis
Thu May 09 00:00:00 EDT 2013
Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer.
International journal of cancer
Guerrero D,Guarch R,Ojer A,Casas JM,Méndez-Meca C,Esteller M,Barba-Ramos E,Garcia-Bragado F,Puras A
MA5-13395 was used in immunohistochemistry to investigate the changes of gene promoter methylation in specific types of vulvar cancer and lichen sclerosus
Wed Jun 15 00:00:00 EDT 2011
Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries.
Journal of cellular physiology
Hohberg M,Knöchel J,Hoffmann CJ,Chlench S,Wunderlich W,Alter A,Maroski J,Vorderwülbecke BJ,Da Silva-Azevedo L,Knudsen R,Lehmann R,Fiedorowicz K,Bongrazio M,Nitsche B,Hoepfner M,Styp-Rekowska B,Pries AR,Zakrzewicz A
MA5-13395 was used in western blot to study the shear stress-dependent expression of ADAMTS1 and its role in regulating angiogenesis
Tue Feb 01 00:00:00 EST 2011
Localization of thrombospondin-1 and myofibroblasts during corneal wound repair.
Experimental eye research
Matsuba M,Hutcheon AE,Zieske JD
MA5-13395 was used in immunohistochemistry to study the expression of thrombospondin-1 and a myofibroblast marker during corneal wound repair
Sat Oct 01 00:00:00 EDT 2011
Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells.
Biochimica et biophysica acta
El Btaouri H,Morjani H,Greffe Y,Charpentier E,Martiny L
MA5-13395 was used in western blot to study the mechanism by which doxorubicin and camptothecin inhibit thrombospondin-1 expression in human thyroid carcinoma cells
Sun May 01 00:00:00 EDT 2011
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis.
Blood
Zaslavsky A,Baek KH,Lynch RC,Short S,Grillo J,Folkman J,Italiano JE,Ryeom S
MA5-13395 was used in immunohistochemistry to investigate the influence of platelet-derived thrombospondin-1 on angiogenesis
Thu Jun 03 00:00:00 EDT 2010
Angiotensin II sustains brain inflammation in mice via TGF-beta.
The Journal of clinical investigation
Lanz TV,Ding Z,Ho PP,Luo J,Agrawal AN,Srinagesh H,Axtell R,Zhang H,Platten M,Wyss-Coray T,Steinman L
MA5-13395 was used in immunohistochemistry to study the role of angiotensin II and TGF-beta in sustaining brain inflammation in a mouse model of multiple sclerosis
Sun Aug 01 00:00:00 EDT 2010
The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.
Cancer research
Dews M,Fox JL,Hultine S,Sundaram P,Wang W,Liu YY,Furth E,Enders GH,El-Deiry W,Schelter JM,Cleary MA,Thomas-Tikhonenko A
MA5-13395 was used in western blot to study the role of clusterin downregulation in promoting angiogenesis and tumor growth
Fri Oct 15 00:00:00 EDT 2010
Opposing effects of bim and bcl-2 on lung endothelial cell migration.
American journal of physiology. Lung cellular and molecular physiology
Grutzmacher C,Park S,Elmergreen TL,Tang Y,Scheef EA,Sheibani N,Sorenson CM
MA5-13395 was used in western blot to study the opposing effects of bim and bcl-2 on lung endothelial cell migration
Mon Nov 01 00:00:00 EDT 2010
PECAM-1 regulates proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactions.
American journal of physiology. Cell physiology
Park S,DiMaio TA,Scheef EA,Sorenson CM,Sheibani N
MA5-13395 was used in western blot to study the mechanisms by which PECAM-1 regulates the proangiogenic properties of endothelial cells
Wed Dec 01 00:00:00 EST 2010
Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy.
Experimental eye research
Tan K,Lessieur E,Cutler A,Nerone P,Vasanji A,Asosingh K,Erzurum S,Anand-Apte B
MA5-13395 was used in western blot to investigate the role of CD34(+) CD45(-) endothelial colony forming cells in proliferative diabetic retinopathy
Sun Aug 01 00:00:00 EDT 2010
Effect of Qingre Quyu Granule (清热祛瘀颗粒) on stabilizing plaques in the brachiocephalic artery of apolipoprotein E deficient mice.
Chinese journal of integrative medicine
Wang Y,Cheng WL,Ke YN,Cai Z,Chen L,Xi Y,Wang P,Guo J,Li H,Huang CX
MA5-13395 was used in immunohistochemistry to investigate the impact of the Chinese herb Qingre Quyu Granule on atherosclerosis and plaques in ApoE deficient mice
Fri Oct 01 00:00:00 EDT 2010
VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment.
BMC cancer
Patten SG,Adamcic U,Lacombe K,Minhas K,Skowronski K,Coomber BL
MA5-13395 was used in western blot to study the effect of heterogeneity in VEGFR2 expression on the response to anti-angiogenic treatment
Wed Dec 15 00:00:00 EST 2010
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors.
Molecular cancer
Olsson A,Björk A,Vallon-Christersson J,Isaacs JT,Leanderson T
MA5-13395 was used in western blot to study the effect of the anti-angiogenic compound Tasquinimod on thrombospondin-1 expression in human prostate cancer cells
Mon May 17 00:00:00 EDT 2010
Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation.
The Journal of biological chemistry
Ikeda H,Miyatake M,Koshikawa N,Ochiai K,Yamada K,Kiss A,Donlin MJ,Panneton WM,Churchill JD,Green M,Siddiqui AM,Leinweber AL,Crews NR,Ezerskiy LA,Rendell VR,Belcheva MM,Coscia CJ
MA5-13395 was used in western blot to study the modulation of thrombospondin-1 levels in astrocytes by morphine and its implications for neurite outgrowth and synapse formation
Fri Dec 03 00:00:00 EST 2010
Vascular endothelial growth factor inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt/eNOS axis in db/db mice.
Diabetes
Park CW,Kim HW,Lim JH,Yoo KD,Chung S,Shin SJ,Chung HW,Lee SJ,Chae CB,Kim YS,Chang YS
MA5-13395 was used in immunohistochemistry to study the harmful cardiac effects of VEGF blockade by dRK6 in type 2 diabetic mice
Sun Nov 01 00:00:00 EDT 2009
Estrogen regulation of thrombospondin-1 in human breast cancer cells.
International journal of cancer
Hyder SM,Liang Y,Wu J
MA5-13395 was used in western blot to study the regulation of thrombospondin-1 expression by estrogen in human breast cancer cells
Tue Sep 01 00:00:00 EDT 2009
Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release.
Thrombosis and haemostasis
Rex S,Beaulieu LM,Perlman DH,Vitseva O,Blair PS,McComb ME,Costello CE,Freedman JE
MA5-13395 was used in immunoprecipitation and western blot to study the different effects of immune versus thrombotic stimulation of platelets
Wed Jul 01 00:00:00 EDT 2009
Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells.
Endocrine-related cancer
Hyder SM,Liang Y,Wu J,Welbern V
MA5-13395 was used in western blot to study the regulation of thrombospondin-1 expression by natural and synthetic progestins in human breast cancer cells
Tue Sep 01 00:00:00 EDT 2009
Attenuation of proliferation and migration of retinal pericytes in the absence of thrombospondin-1.
American journal of physiology. Cell physiology
Scheef EA,Sorenson CM,Sheibani N
MA5-13395 was used in western blot to study the role of thrombospondin-1 in retinal pericyte proliferation and migration
Wed Apr 01 00:00:00 EDT 2009
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation.
Nitric oxide : biology and chemistry
Isenberg JS,Shiva S,Gladwin M
MA5-13395 was used in blocking or activating experiment to study the mechanisms by which thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival
Sat Aug 01 00:00:00 EDT 2009
Differential expression of pancreatitis-associated protein and thrombospondins in arterial versus venous tissues.
Journal of vascular research
Szasz T,Eddy S,Paulauskis J,Burnett R,Ellekilde M,Iovanna JL,Watts SW
MA5-13395 was used in immunohistochemistry to compare the expression of pancreatitis-associated protein and thrombospondins between arterial and venous tissues
Thu Oct 29 00:00:00 EDT 2009
Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation.
American journal of physiology. Renal physiology
Daniel C,Wagner A,Hohenstein B,Hugo C
MA5-13395 was used in immunohistochemistry to study the improvement of thrombospondin-2 therapy on experimental glomerulonephritis and its mechanism
Sun Nov 01 00:00:00 EDT 2009
Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain.
Translational research : the journal of laboratory and clinical medicine
Gayen Betal S,Setty BN
MA5-13395 was used in blocking or activating experiment to investigate the role of the heparin-binding domain of the phosphatidylserine-positive erythrocytes in its binding to immobilized and soluble thrombosphodin-1
Wed Oct 01 00:00:00 EDT 2008
Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets.
Diabetes
Olerud J,Johansson M,Lawler J,Welsh N,Carlsson PO
MA5-13395 was used in western blot to study the effect thrombospondin-1 inhibition on vascular engraftment and graft function in mouse pancreatic islets
Tue Jul 01 00:00:00 EDT 2008
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
Oncogene
Mazan-Mamczarz K,Hagner PR,Corl S,Srikantan S,Wood WH,Becker KG,Gorospe M,Keene JD,Levenson AS,Gartenhaus RB
MA5-13395 was used in western blot to study the role of post-transcriptional gene regulation by RNA-binding protein HuR in promoting tumorigenesis
Thu Oct 16 00:00:00 EDT 2008
The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.
International journal of cancer
Rojas A,Meherem S,Kim YH,Washington MK,Willis JE,Markowitz SD,Grady WM
MA5-13395 was used in immunohistochemistry and western blot to study the effect of aberrant methylation of thrombospondin-1 on TGF-beta1 activation in colorectal cancer
Tue Jul 01 00:00:00 EDT 2008
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
BJU international
Guerrero D,Guarch R,Ojer A,Casas JM,Ropero S,Mancha A,Pesce C,Lloveras B,Garcia-Bragado F,Puras A
MA5-13395 was used in immunohistochemistry to investigate the prognostic significance of thrombospondin-1 hypermethylation in penile squamous cell carcinoma
Mon Sep 01 00:00:00 EDT 2008
Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling.
The American journal of pathology
Anderson CR,Hastings NE,Blackman BR,Price RJ
MA5-13395 was used in blocking or activating experiment to investigate the phenotypical transition of endothelial cells from quiescence to an angiogenic state
Wed Oct 01 00:00:00 EDT 2008
Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc.
Arthritis research & therapy
Gruber HE,Bornstein P,Sage EH,Ingram JA,Zinchenko N,Norton HJ,Hanley EN
MA5-13395 was used in immunohistochemistry to examine the role of thrombospondin genes in the vascularization of the adult mouse lumbar disc
Fri Feb 06 00:00:00 EST 2009
High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs.
American journal of physiology. Cell physiology
Huang Q,Sheibani N
MA5-13395 was used in western blot to study the molecular mechanism by which high glucose promotes retinal endothelial cell migration
Mon Dec 01 00:00:00 EST 2008
Attenuation of retinal endothelial cell migration and capillary morphogenesis in the absence of bcl-2.
American journal of physiology. Cell physiology
Kondo S,Tang Y,Scheef EA,Sheibani N,Sorenson CM
MA5-13395 was used in western blot to study the role of bcl-2 in retinal endothelial cell migration and capillary morphogenesis
Sun Jun 01 00:00:00 EDT 2008
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Respiratory medicine
Ide M,Ishii H,Mukae H,Iwata A,Sakamoto N,Kadota J,Kohno S
MA5-13395 was used in immunohistochemistry to investigate the role of thrombospondin-1 in idiopathic interstitial pneumonia
Sat Nov 01 00:00:00 EDT 2008
Treatment of liver ischemia-reperfusion injury by limiting thrombospondin-1/CD47 signaling.
Surgery
Isenberg JS,Maxhimer JB,Powers P,Tsokos M,Frazier WA,Roberts DD
MA5-13395 was used in immunohistochemistry to investigate the effect of TSP-1/CD47 blockade on liver ischemia-reperfusion injury
Sat Nov 01 00:00:00 EDT 2008
Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose.
The Journal of biological chemistry
Bhattacharyya S,Marinic TE,Krukovets I,Hoppe G,Stenina OI
MA5-13395 was used in immunoprecipitation to study the cell type-specific regulation of production of thrombospondin-1 by high glucose
Fri Feb 29 00:00:00 EST 2008
Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1.
BMC urology
Johnson AM,O'Connell MJ,Miyamoto H,Huang J,Yao JL,Messing EM,Reeder JE
MA5-13395 was used in immunohistochemistry to study the role of thrombospondin-1 in the androgenic dependence of exophytic tumor growth in a transgenic model of bladder cancer
Wed Apr 23 00:00:00 EDT 2008
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation.
Blood
Isenberg JS,Hyodo F,Matsumoto K,Romeo MJ,Abu-Asab M,Tsokos M,Kuppusamy P,Wink DA,Krishna MC,Roberts DD
MA5-13395 was used in immunohistochemistry to study the mechanism by which thrombospondin-1 limits ischemic tissue survival
Thu Mar 01 00:00:00 EST 2007
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
Blood
Duvic M,Talpur R,Ni X,Zhang C,Hazarika P,Kelly C,Chiao JH,Reilly JF,Ricker JL,Richon VM,Frankel SR
MA5-13395 was used in immunohistochemistry to evaluate a phase 2 clinical trial of oral vorinostat for refractory cutaneous T-cell lymphoma
Mon Jan 01 00:00:00 EST 2007
Increasing survival of ischemic tissue by targeting CD47.
Circulation research
Isenberg JS,Romeo MJ,Abu-Asab M,Tsokos M,Oldenborg A,Pappan L,Wink DA,Frazier WA,Roberts DD
MA5-13395 was used in immunohistochemistry to investigate the role of CD47 in the survival of ischemic tissue
Fri Mar 16 00:00:00 EDT 2007
Bcl-2 expression modulates cell adhesion and migration promoting branching of ureteric bud cells.
Journal of cellular physiology
Sheibani N,Scheef EA,Dimaio TA,Wang Y,Kondo S,Sorenson CM
MA5-13395 was used in western blot to study the role of the bcl-2 in the adhesion and migration of ureteric bud cells
Thu Mar 01 00:00:00 EST 2007
Thrombospondin-1 expression and localization in the developing ovine lung.
The Journal of physiology
Sozo F,Hooper SB,Wallace MJ
MA5-13395 was used in immunohistochemistry to study the expression and localization of thrombospondin-1 in the developing ovine lung
Mon Oct 15 00:00:00 EDT 2007
Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts.
Arthritis research & therapy
Pohlers D,Beyer A,Koczan D,Wilhelm T,Thiesen HJ,Kinne RW
MA5-13395 was used in immunohistochemistry to examine the alteration of transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts
Thu Jan 31 00:00:00 EST 2008
Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1.
Journal of immunology (Baltimore, Md. : 1950)
Derks RA,Jankowska-Gan E,Xu Q,Burlingham WJ
MA5-13395 was used in blocking or activating experiment to study the mechanism of bystander suppression by donor antigen-specific T regulatory cells in patients with organ transplant tolerance
Sat Sep 15 00:00:00 EDT 2007
PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis.
American journal of physiology. Cell physiology
Kondo S,Scheef EA,Sheibani N,Sorenson CM
MA5-13395 was used in western blot to study the role of PECAM-1 in kidney endothelial cell migration and capillary morphogenesis
Fri Jun 01 00:00:00 EDT 2007
The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats.
Nitric oxide : biology and chemistry
de Nigris F,Balestrieri ML,Williams-Ignarro S,D'Armiento FP,Fiorito C,Ignarro LJ,Napoli C
MA5-13395 was used in immunohistochemistry to study the effect of pomegranate preparations on nitric oxide and arterial function in obese Zucker rats
Wed Aug 01 00:00:00 EDT 2007
PPARalpha deficiency in inflammatory cells suppresses tumor growth.
PloS one
Kaipainen A,Kieran MW,Huang S,Butterfield C,Bielenberg D,Mostoslavsky G,Mulligan R,Folkman J,Panigrahy D
MA5-13395 was used in immunohistochemistry to study the effect of PPARalpha deficiency in inflammatory cells on tumor growth
Wed Feb 28 00:00:00 EST 2007
Glycosylation mediates up-regulation of a potent antiangiogenic and proatherogenic protein, thrombospondin-1, by glucose in vascular smooth muscle cells.
The Journal of biological chemistry
Raman P,Krukovets I,Marinic TE,Bornstein P,Stenina OI
MA5-13395 was used in immunocytochemistry to investigate the effect of hexosamine pathway and intracellular glycosylation on atherosclerotic lesions
Fri Feb 23 00:00:00 EST 2007
Isolation and characterization of corneal endothelial cells from wild type and thrombospondin-1 deficient mice.
Molecular vision
Scheef EA,Huang Q,Wang S,Sorenson CM,Sheibani N
MA5-13395 was used in western blot to isolate and characterize primary corneal endothelial cells from wild type and thrombospondin-1 knockout mice
Mon Aug 27 00:00:00 EDT 2007
Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations.
The Journal of biological chemistry
Annis DS,Gunderson KA,Mosher DF
MA5-13395 was used in ELISA to probe the structure of thrombospondin-1 and thrombospondin-2 signature domains at low calcium concentration using conformation-sensitive monoclonal antibodies
Fri Sep 14 00:00:00 EDT 2007
Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.
The Journal of clinical investigation
Kopp HG,Hooper AT,Broekman MJ,Avecilla ST,Petit I,Luo M,Milde T,Ramos CA,Zhang F,Kopp T,Bornstein P,Jin DK,Marcus AJ,Rafii S
MA5-13395 was used in immunohistochemistry to investigate the role of thrombospondins in angiogenesis
Fri Dec 01 00:00:00 EST 2006
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.
Proceedings of the National Academy of Sciences of the United States of America
Giuriato S,Ryeom S,Fan AC,Bachireddy P,Lynch RC,Rioth MJ,van Riggelen J,Kopelman AM,Passegué E,Tang F,Folkman J,Felsher DW
MA5-13395 was used in immunohistochemistry to investigate the importance of p53 and TSP-1 in tumor regression induced by MYC inactivation
Tue Oct 31 00:00:00 EST 2006
Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes.
Diabetes
Shoji T,Koyama H,Morioka T,Tanaka S,Kizu A,Motoyama K,Mori K,Fukumoto S,Shioi A,Shimogaito N,Takeuchi M,Yamamoto Y,Yonekura H,Yamamoto H,Nishizawa Y
MA5-13395 was used in immunohistochemistry to study the role of RAGE in impaired angiogenic response in diabetes
Tue Aug 01 00:00:00 EDT 2006
HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy.
Oncogene
Wen XF,Yang G,Mao W,Thornton A,Liu J,Bast RC,Le XF
MA5-13395 was used in immunohistochemistry to examine the regulatory roles of HER2 in angiogenesis
Thu Nov 02 00:00:00 EST 2006
Expression of thrombospondin 1 (TSP 1) in patients with uterine smooth muscle tumors: an immunohistochemical study.
Gynecologic oncology
Bodner-Adler B,Nather A,Bodner K,Czerwenka K,Kimberger O,Leodolter S,Mayerhofer K
MA5-13395 was used in immunohistochemistry to study the immunohistochemical expression of thrombospondin-1 in uterine smooth muscle tumors
Sun Oct 01 00:00:00 EDT 2006
Versican-thrombospondin-1 binding in vitro and colocalization in microfibrils induced by inflammation on vascular smooth muscle cells.
Journal of cell science
Kuznetsova SA,Issa P,Perruccio EM,Zeng B,Sipes JM,Ward Y,Seyfried NT,Fielder HL,Day AJ,Wight TN,Roberts DD
MA5-13395 was used in immunocytochemistry to study the effects of inflammation on versican-thrombospondin-1 binding in vitro and colocalization in microfibrils
Wed Nov 01 00:00:00 EST 2006
Islet endothelial cells and pancreatic beta-cell proliferation: studies in vitro and during pregnancy in adult rats.
Endocrinology
Johansson M,Mattsson G,Andersson A,Jansson L,Carlsson PO
MA5-13395 was used in immunohistochemistry to investigate the proliferation of islet endothelial cells and pancreatic beta-cell in adult rats
Mon May 01 00:00:00 EDT 2006
Gene expression changes evoked in a venous segment exposed to arterial flow.
Journal of vascular surgery
Abeles D,Kwei S,Stavrakis G,Zhang Y,Wang ET,García-Cardeña G
MA5-13395 was used in immunohistochemistry to study the effects on gene expression of exposing a vein to arterial flow
Sun Oct 01 00:00:00 EDT 2006
Enhanced proangiogenic signaling in thrombospondin-1-deficient retinal endothelial cells.
Microvascular research
Wang Y,Wang S,Sheibani N
MA5-13395 was used in western blot to determine the role of thrombospondin-1 in angiogenesis in retinal endothelial cells
Mon May 01 00:00:00 EDT 2006
1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression.
Kidney international
Li Y,Spataro BC,Yang J,Dai C,Liu Y
MA5-13395 was used in western blot to study the mechanism by which 1,25-dihydroxyvitamin D inhibits the activation of renal interstitial myofibroblasts
Sat Oct 01 00:00:00 EDT 2005
Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sutton CD,O'Byrne K,Goddard JC,Marshall LJ,Jones L,Garcea G,Dennison AR,Poston G,Lloyd DM,Berry DP
MA5-13395 was used in immunohistochemistry to study the expression and prognostic significance of thrombospondin-1 in resected colorectal liver metastases
Thu Sep 15 00:00:00 EDT 2005
Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling.
Proceedings of the National Academy of Sciences of the United States of America
Olson LE,Zhang J,Taylor H,Rose DW,Rosenfeld MG
MA5-13395 was used in immunohistochemistry to study the mechanism by which Barx regulates the remodeling of hair follicles
Tue Mar 08 00:00:00 EST 2005
Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor.
Matrix biology : journal of the International Society for Matrix Biology
Isenberg JS,Calzada MJ,Zhou L,Guo N,Lawler J,Wang XQ,Frazier WA,Roberts DD
MA5-13395 was used in ELISA to study the role of thrombospondin-1 in the proliferation of vascular smooth muscle cells and their responses to PDGF
Fri Apr 01 00:00:00 EST 2005
Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition.
Hypertension (Dallas, Tex. : 1979)
Bouvet C,Gilbert LA,Girardot D,deBlois D,Moreau P
MA5-13395 was used in western blot to study the extracellular matrix components involved in remodelling small and large arteries during chronic NO synthase inhibition
Tue Mar 01 00:00:00 EST 2005
Increased expression of protein C-mannosylation in the aortic vessels of diabetic Zucker rats.
Glycobiology
Ihara Y,Manabe S,Kanda M,Kawano H,Nakayama T,Sekine I,Kondo T,Ito Y
MA5-13395 was used in immunohistochemistry, immunoprecipitation, and western blot to study the increased levels of C-mannosylation of proteins in the aortic vessels of diabetic Zucker rats
Fri Apr 01 00:00:00 EST 2005
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch.
The American journal of pathology
Cambier S,Gline S,Mu D,Collins R,Araya J,Dolganov G,Einheber S,Boudreau N,Nishimura SL
MA5-13395 was used in western blot to study the molecular mechanisms underlying astrocytic-endothelial paracrine signaling
Wed Jun 01 00:00:00 EDT 2005
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Cancer biology & therapy
Jo WS,Mizukami Y,Duerr EM,Zukerberg LR,Chung DC
MA5-13395 was used in immunohistochemistry and western blot to study the role of Wnt signaling in repressing thrombospondin-1 expression in colonic tumorigenesis
Thu Dec 01 00:00:00 EST 2005
Kinetics of biglycan, decorin and thrombospondin-1 in mercuric chloride-induced renal tubulointerstitial fibrosis.
Experimental and molecular pathology
Suzuki K,Wang R,Kubota H,Shibuya H,Saegusa J,Sato T
MA5-13395 was used in immunohistochemistry to study the expression of biglycan, decorin and thrombospondin-1 during mercuric chloride-induced renal tubulointerstitial fibrosis
Mon Aug 01 00:00:00 EDT 2005
Thrombospondins, metallo proteases and thrombospondin receptors messenger RNA and protein expression in different tumour sublines of the Dunning prostate cancer model.
Acta oncologica (Stockholm, Sweden)
Vallbo C,Damber JE
MA5-13395 was used in immunohistochemistry to study the expression of thrombospondins, metallo proteases and thrombospondin receptors in different sublines of Dunning prostate cancer model
Tue Sep 27 00:00:00 EDT 2005
Impairment of thrombospondin-1 expression during epithelial wound healing in corneas of vitamin A-deficient mice.
Histology and histopathology
Uno K,Kuroki M,Hayashi H,Uchida H,Kuroki M,Oshima K
MA5-13395 was used in immunohistochemistry to study the expression of thrombospondin-1 during re-epithelialization in wounded corneas of vitamin A-deficient mice
Fri Apr 01 00:00:00 EST 2005
Isolation and characterization of murine retinal astrocytes.
Molecular vision
Scheef E,Wang S,Sorenson CM,Sheibani N
MA5-13395 was used in western blot to isolate and characterize primary retinal astrocytes from wild-type and thrombospondin-1-deficient transgenic mice
Mon Aug 22 00:00:00 EDT 2005
Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol.
Molecular cancer research : MCR
Sengupta K,Banerjee S,Saxena NK,Banerjee SK
MA5-13395 was used in western blot to study the role of thrombospondin-1 in estrogen-induced endothelial cell proliferation and migration
Mon Mar 01 00:00:00 EST 2004
Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice.
American journal of physiology. Renal physiology
Ziehr J,Sheibani N,Sorenson CM
MA5-13395 was used in western blot to study altered cell-adhesion and migratory mechanisms during renal maturation in bcl-2 -/- mice
Wed Dec 01 00:00:00 EST 2004
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro.
Experimental eye research
Flügel-Koch C,Ohlmann A,Fuchshofer R,Welge-Lüssen U,Tamm ER
MA5-13395 was used in immunohistochemistry to study the expression and localiation of thrombospondin-1 in the trabecular meshwork in normal and glaucomatous eyes
Mon Nov 01 00:00:00 EST 2004
Thrombospondin-1 accelerates wound healing of corneal epithelia.
Biochemical and biophysical research communications
Uno K,Hayashi H,Kuroki M,Uchida H,Yamauchi Y,Kuroki M,Oshima K
MA5-13395 was used in immunohistochemistry to study the role of thrombospondin-1 in corneal epithelial wound healing
Fri Mar 19 00:00:00 EST 2004
Role of thrombospondin-1 in the autologous phase of an accelerated model of anti-glomerular basement membrane glomerulonephritis.
Nephron. Experimental nephrology
Hochegger K,Knight S,Hugo C,Mayer G,Lawler J,Mayadas TN,Rosenkranz AR
MA5-13395 was used in immunohistochemistry to investigate the involvement of thrombospondin 1 in glomerulonephritis
Mon May 10 00:00:00 EDT 2004
Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat.
Circulation
Stenina OI,Krukovets I,Wang K,Zhou Z,Forudi F,Penn MS,Topol EJ,Plow EF
MA5-13395 was used in immunohistochemistry to study the expression of thrombospondin-1 in the blood vessel wall of diabetic Zucker rats
Tue Jul 01 00:00:00 EDT 2003
Regulation of multiple tumor microenvironment markers by overexpression of single or paired combinations of ErbB receptors.
Cancer research
Alaoui-Jamali MA,Song DJ,Benlimame N,Yen L,Deng X,Hernandez-Perez M,Wang T
MA5-13395 was used in immunohistochemistry to study the effect of ErbB receptor overexpression on multiple tumor microenvironment markers
Tue Jul 01 00:00:00 EDT 2003
Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells.
Experimental eye research
Liu X,Wu Z,Sheibani N,Brandt CR,Polansky JR,Kaufman PL
MA5-13395 was used in western blot to study the effect of low dose latrunculin-A on dexamethasone-induced changes in the cytoskeleton and ECM of human trabecular meshwork cells
Fri Aug 01 00:00:00 EDT 2003
Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Salvesen HB,Gulluoglu MG,Stefansson I,Akslen LA
MA5-13395 was used in immunohistochemistry to study the prognostic significance and role of CD 105 in endometrial carcinomas
Sat Nov 01 00:00:00 EST 2003
Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms.
Cell communication & adhesion
Qin H,Shao Q,Thomas T,Kalra J,Alaoui-Jamali MA,Laird DW
MA5-13395 was used in western blot to study the mechanisms by which connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells
Mon Nov 15 00:00:00 EST 2004
Isolation and characterization of murine retinal endothelial cells.
Molecular vision
Su X,Sorenson CM,Sheibani N
MA5-13395 was used in western blot to develop a method for the isolation and chacterization retinal endothelial cells from mice
Thu May 01 00:00:00 EDT 2003
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.
Cancer research
Kragh M,Quistorff B,Tenan M,Van Meir EG,Kristjansen PE
MA5-13395 was used in western blot to study the effect of thrombospondin-1 overexpression on tumor growth, vascularity, and perfusion in glioblastoma
Fri Feb 15 00:00:00 EST 2002
Characteristics of long-term survivors of untreated lung cancer.
Lung cancer (Amsterdam, Netherlands)
Mattern J,Koomägi R,Volm M
MA5-13395 was used in immunohistochemistry to study the characteristics of long-term survivors of untreated non-small cell lung cancer
Sat Jun 01 00:00:00 EDT 2002
In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin.
Investigative ophthalmology & visual science
Filla MS,Liu X,Nguyen TD,Polansky JR,Brandt CR,Kaufman PL,Peters DM
MA5-13395 was used in immunocytochemistry to investigate the association of TIGR/MYOC with trabecular meshwork extracellular matrix
Tue Jan 01 00:00:00 EST 2002
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Journal of clinical pathology
Rice AJ,Steward MA,Quinn CM
MA5-13395 was used in immunohistochemistry to study the prognostic significance of thrombospondin-1 protein expression in ductal carcinoma in situ of the breast
Sun Dec 01 00:00:00 EST 2002
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Journal of clinical pathology
Rice AJ,Steward MA,Quinn CM
MA5-13395 was used in immunohistochemistry to study the prognostic significance of thrombospondin-1 protein expression in ductal carcinoma in situ of the breast
Sun Dec 01 00:00:00 EST 2002
Investigation of the role of nitric oxide synthase 2 in pregnancy using mutant mice.
Reproduction (Cambridge, England)
Burnett TG,Tash JS,Hunt JS
MA5-13395 was used in immunohistochemistry to investigate the effect of nitric oxide synthetase 2 on decidual cellular integrity and the development of uterine vasculature
Mon Jul 01 00:00:00 EDT 2002
Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice.
Developmental dynamics : an official publication of the American Association of Anatomists
Flügel-Koch C,Ohlmann A,Piatigorsky J,Tamm ER
MA5-13395 was used in immunohistochemistry to study the role of TGF-beta1 overexpression in anterior segment development in the eyes of transgenic mice
Tue Oct 01 00:00:00 EDT 2002
