Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
BSM-51289M
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
5A3
Immunogen
This Tyro3 antibody is generated from a mouse immunized with a recombinant protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
TBS, pH 7.4, with 1% BSA, 40% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Etk2/tyro3; FLJ16467; soluble tyro 3; soluble tyro3; styro 3; styro3; TK19-2; tyro 3; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase TIF
Gene Aliases: AI323366; Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif; TK19-2; Tyro3
UniProt ID: (Mouse) P55144
Entrez Gene ID: (Mouse) 22174
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphatidylinositol 3-kinase binding
protein heterodimerization activity
transmembrane signal receptor
natural killer cell differentiation
protein phosphorylation
cell adhesion
spermatogenesis
phosphorylation
peptidyl-tyrosine phosphorylation
forebrain cell migration
platelet activation
secretion by cell
negative regulation of toll-like receptor signaling pathway
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
negative regulation of innate immune response
protein autophosphorylation
negative regulation of inflammatory response
negative regulation of lymphocyte activation
vagina development
neuron cellular homeostasis
platelet aggregation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support