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Product Details
BS-6308R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human UACA, amino acids 311-410.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-actin-binding protein; BetaCAP73; nuclear membrane binding protein; nuclear membrane binding protein NUCLING; Nuclear membrane-binding protein; Nucling; uveal autoantigen with coiled coil domains and ankyrin repeats; Uveal autoantigen with coiled-coil domains and ankyrin repeats; Uveal autoantigen with coiled-coil domains and ankyrin repeats protein
Gene Aliases: 2700059D02Rik; KIAA1561; NUCLING; RGD1560011; UACA
UniProt ID: (Bovine) Q8HYY4, (Human) Q9BZF9, (Mouse) Q8CGB3
Entrez Gene ID: (Bovine) 281559, (Human) 55075, (Mouse) 72565, (Rat) 315732
apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
intrinsic apoptotic signaling pathway in response to oxidative stress
response to UV
positive regulation of protein import into nucleus
negative regulation of NF-kappaB import into nucleus
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of inflammatory response
regulation of NIK/NF-kappaB signaling
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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