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Product Details
10224-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UBC9 Fusion Protein Ag0252 (1-158 aa encoded by BC000427)
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
In heart and muscle extracts the UBE2I antibodies recognizes a 38 kDa protein band, but this band is not visible in extracts of other rat tissues.
Immunogen sequence: MSGIALSRL AQERKAWRKD HPFGFVAVPT KNPDGTMNLM NWECAIPGKK GTPWEGGLFK LRMLFKDDYP SSPPKCKFEP PLFHPNVYPS GTVCLSILEE DKDWRPAITI KQILLGIQEL LNEPNIQDPA QAEAYTIYCQ NRVEYEKRVR AQAKKFAPS (1-158 aa encoded by BC000427 )
Target Information
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mUBC9; OTTHUMP00000198131; p18; RING-type E3 SUMO transferase UBC9; SUMO-1-protein ligase; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; ubiquitin conjugating enzyme 9; ubiquitin conjugating enzyme E2I; Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9); Ubiquitin-conjugating enzyme E2 I; ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9); ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); Ubiquitin-conjugating enzyme UbcE2A; ubiquitin-like protein SUMO-1 conjugating enzyme; ubiquitin-protein ligase E2I; Ubiquitin-protein ligase I
Gene Aliases: 5830467E05Rik; C358B7.1; F830028O17Rik; P18; UBC9; UbcE2A; Ubce2i; UBCE9; UBE2I
UniProt ID: (Human) P63279, (Rat) P63281, (Mouse) P50550
Entrez Gene ID: (Human) 7329, (Rat) 25573, (Mouse) 22196
protein binding
ATP binding
transcription factor binding
ligase activity
SUMO transferase activity
enzyme binding
ubiquitin protein ligase binding
HLH domain binding
poly(A) RNA binding
ubiquitin protein ligase activity
SUMO conjugating enzyme activity
RING-like zinc finger domain binding
ubiquitin-protein transferase activity
protein C-terminus binding
bHLH transcription factor binding
nucleotide binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
negative regulation of transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
chromosome segregation
mitotic nuclear division
regulation of receptor activity
protein ubiquitination
protein sumoylation
positive regulation of intracellular steroid hormone receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
cell division
positive regulation of SUMO transferase activity
cellular protein modification process
viral process
global genome nucleotide-excision repair
cell cycle
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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