Proteintech

UBE4B Polyclonal Antibody

UBE4B Antibody in Immunocytochemistry (ICC/IF)

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UBE4B Antibody (18148-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 18148-1-AP (UBE4B antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

UBE4B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

UBE4B Antibody in Immunoprecipitation (IP)

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Product Details

18148-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

UBE4B Fusion Protein Ag12836 (825-1173 aa encoded by BC093696)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EMIENHPLS TKLLVPSLMK FYTDVEHTGA TSEFYDKFTI RYHISTIFKS LWQNIAHHGT FMEEFNSGKQ FVRYINMLIN DTTFLLDESL ESLKRIHEVQ EEMKNKEQWD QLPRDQQQAR QSQLAQDERV SRSYLALATE TVDMFHILTK QVQKPFLRPE LGPRLAAMLN FNLQQLCGPK CRDLKVENPE KYGFEPKKLL DQLTDIYLQL DCARFAKAIA DDQRSYSKEL FEEVISKMRK AGIKSTIAIE KFKLLAEKVE EIVAKNARAE IDYSDAPDEF RDPLMDTLMT DPVRLPSGTI MDRSIILRHL LNSPTDPFNR QTLTESMLEP VPELKEQIQA WMREKQNSDH (825-1173 aa encoded by BC093696)

Target Information

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B represents an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. UBE4B also the strongest candidate among the neuroblastoma tumor suppressors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.

Biochimica et biophysica acta. Gene regulatory mechanisms

Hu X,Zou R,Zhang Z,Ji J,Li J,Huo XY,Liu D,Ge MX,Cui MK,Wu MZ,Li ZP,Wang Q,Zhang X,Zhang ZR

Thu Jun 01 00:00:00 EDT 2023

UBE4B promotes the development of lung adenocarcinoma by enhancing proliferation, migration and glycolysis via PP2A/AKT signaling.

Pathology, research and practice

Wu S,Xie L,Cheng S,Fan Z,Sang H,Li Q

Fri Apr 01 00:00:00 EDT 2022

RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins.

Molecular cell

Hu X,Wang L,Wang Y,Ji J,Li J,Wang Z,Li C,Zhang Y,Zhang ZR

Thu Jul 16 00:00:00 EDT 2020

The Roles of Ubiquitination Factor E4B (UBE4B) in the Postoperative Prognosis of Patients with Renal Cell Carcinoma and in Renal Tumor Cells Growth and Metastasis.

OncoTargets and therapy

Huang XQ,Hao S,Zhou ZQ,Huang B,Fang JY,Tang Y,Zhang JH,Xia JC

Tue Apr 12 00:00:00 EDT 2022

The Roles of Ubiquitination Factor E4B (UBE4B) in the Postoperative Prognosis of Patients with Renal Cell Carcinoma and in Renal Tumor Cells Growth and Metastasis.

OncoTargets and therapy

Huang XQ,Hao S,Zhou ZQ,Huang B,Fang JY,Tang Y,Zhang JH,Xia JC

Tue Apr 12 00:00:00 EDT 2022

Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.

Molecular carcinogenesis

Zhang XF,Pan QZ,Pan K,Weng DS,Wang QJ,Zhao JJ,He J,Liu Q,Wang DD,Jiang SS,Zheng HX,Lv L,Chen CL,Zhang HX,Xia JC

Fri Jan 01 00:00:00 EST 2016

Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.

Molecular carcinogenesis

Zhang XF,Pan QZ,Pan K,Weng DS,Wang QJ,Zhao JJ,He J,Liu Q,Wang DD,Jiang SS,Zheng HX,Lv L,Chen CL,Zhang HX,Xia JC

Fri Jan 01 00:00:00 EST 2016

SILAC-based quantitative proteomic analysis of secretome between activated and reverted hepatic stellate cells.

Proteomics

Zhang H,Wu P,Chen F,Hao Y,Lao Y,Ren L,Sun L,Sun W,Wei H,Chan DW,Jiang Y,He F

Mon Sep 01 00:00:00 EDT 2014

SILAC-based quantitative proteomic analysis of secretome between activated and reverted hepatic stellate cells.

Proteomics

Zhang H,Wu P,Chen F,Hao Y,Lao Y,Ren L,Sun L,Sun W,Wei H,Chan DW,Jiang Y,He F

Mon Sep 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: homologous to yeast UFD2; Homozygously deleted in neuroblastoma 1; homozygously deleted in neuroblastoma-1; RING-type E3 ubiquitin transferase E4 B; Ubiquitin conjugation factor E4 B; Ubiquitin fusion degradation protein 2; ubiquitin-fusion degradation protein 2; ubiquitination factor E4B (homologous to yeast UFD2); ubiquitination factor E4B (UFD2 homolog, yeast); ubiquitination factor E4B, UFD2 homolog; UFD2A-III/UBE4B-III splice isoform

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Gene Aliases: 4930551I19Rik; 4933406G05Rik; AU014668; D4Bwg0973e; E4; HDNB1; KIAA0684; mKIAA0684; UBE4B; UBOX3; UFD2; UFD2A; Ufd2p

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UniProt ID: (Human) O95155, (Mouse) Q9ES00

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Entrez Gene ID: (Human) 10277, (Mouse) 63958, (Rat) 298652

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Function(s)

ATP binding ligase activity enzyme binding ubiquitin-ubiquitin ligase activity ATPase binding protein binding ubiquitin protein ligase activity ubiquitin-protein ligase protein modifying enzyme

Process(es)

protein polyubiquitination ventricular trabecula myocardium morphogenesis protein monoubiquitination granzyme-mediated apoptotic signaling pathway response to UV neuron projection development response to endoplasmic reticulum stress protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination ubiquitin-dependent protein catabolic process protein ubiquitination cellular protein catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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UBE4B Polyclonal Antibody

UBE4B Antibody (18148-1-AP) in ICC/IF

Product Details

18148-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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