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FIGURE: 1 / 1
UGDH Antibody (PA5-88347) in WB
Western blot analysis of UGDH in extracts of various cell lines. Samples were incubated with UGDH Polyclonal antibody (Product # PA5-88347) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product Details
PA5-88347
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 165-494 of human UGDH (NP_0033501)
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804846
Product Specific Information
Immunogen sequence: EGTAIKDLKN PDRVLIGGDE TPEGQRAVQA LCAVYEHWVP REKILTTNTW SSELSKLAAN AFLAQRISSI NSISALCEAT GADVEEVATA IGMDQRIGNK FLKASVGFGG SCFQKDVLNL VYLCEALNLP EVARYWQQVI DMNDYQRRRF ASRIIDSLFN TVTDKKIAIL GFAFKKDTGD TRESSSIYIS KYLMDEGAHL HIYDPKVPRE QIVVDLSHPG VSEDDQVSRL VTISKDPYEA CDGAHAVVIC TEWDMFKELD YERIHKKMLK PAFIFDGRRV LDGLHNELQT IGFQIETIGK KVSSKRIPYA PSGEIPKFSL QDPPNKKPKV; Positive Samples: HeLa, THP-1, 22Rv1, ES-2, U-937, Mouse kidney, Mouse intestine
Target Information
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: UDP UGD; UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogenase; uridine diphospho-glucose dehydrogenase
Gene Aliases: GDH; UDP-GlcDH; UDPGDH; UGD; UGDH
UniProt ID: (Human) O60701, (Mouse) O70475
Entrez Gene ID: (Human) 7358, (Mouse) 22235
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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