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Product Details
PA5-104192
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human UBQLN2(Accession Q9UHD9), corresponding to amino acid residues S527-N577.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2853520
Product Specific Information
Antibody detects endogenous levels of total UBQLN2.
Target Information
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chap1; DSK2 homolog; Nedd4 binding protein 4; PLIC-2; Protein linking IAP with cytoskeleton 2; Ubiquilin-2; Ubiquitin-like product Chap1/Dsk2; Ubiquitin-related protein
Gene Aliases: ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; Plic-2; PLIC2; RGD1563566; UBQLN2
UniProt ID: (Human) Q9UHD9, (Mouse) Q9QZM0
Entrez Gene ID: (Human) 29978, (Mouse) 54609, (Rat) 317396
regulation of macroautophagy
ER-associated ubiquitin-dependent protein catabolic process
negative regulation of clathrin-mediated endocytosis
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
negative regulation of G-protein coupled receptor internalization
regulation of autophagosome assembly
autophagy
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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