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NeoBiotechnologies
VLDL-Receptor (Very Low Density Lipoprotein Receptor) Recombinant Mouse Monoclonal Antibody (rVLDLR/1337)
FIGURE: 1 / 2
VLDL-Receptor (Very Low Density Lipoprotein Receptor) Antibody (7436-MSM3-P1) in IHC (P)
Formalin-fixed, paraffin-embedded human pancreas stained with VLDL-Receptor Recombinant Mouse Monoclonal Antibody (rVLDLR/1337). Inset: PBS instead of primary antibody; secondary only negative control.
Product Details
7436-MSM3-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
rVLDLR/1337
Immunogen
Recombinant human VLDLR fragment from c-terminal
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Antibody is stable for 24 months.
Positive Control: HeLaor U-251 cells.Human pancreas, cerebellum, heart or skeletal muscle. Cellular Localization: Cytoplasmic
Specificity Comments: VLDLR (very low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDLR is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.
Target Information
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ35024; Very low-density lipoprotein receptor; VLDL receptor; VLDL-R
Gene Aliases: CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLR; VLDLRCH
UniProt ID: (Human) P98155
Entrez Gene ID: (Human) 7436, (Rat) 25696
glycoprotein binding
low-density lipoprotein receptor activity
calcium ion binding
protein binding
very-low-density lipoprotein particle receptor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
glycoprotein transporter activity
reelin receptor activity
calcium-dependent protein binding
protein tyrosine kinase activator activity
apolipoprotein
negative regulation of transcription from RNA polymerase II promoter
lipid transport
receptor-mediated endocytosis
signal transduction
nervous system development
heart development
response to nutrient
memory
cholesterol metabolic process
ventral spinal cord development
cerebral cortex development
cellular response to insulin stimulus
glycoprotein transport
very-low-density lipoprotein particle clearance
reelin-mediated signaling pathway
cellular response to glucose starvation
response to drug
positive regulation of protein kinase activity
dendrite morphogenesis
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to hypoxia
positive regulation of dendrite development
response to hypoxia
cell surface receptor signaling pathway
response to hormone
response to lipopolysaccharide
positive regulation of protein tyrosine kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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