Proteintech

WAPL/WAPAL Polyclonal Antibody

WAPL/WAPAL Antibody in Western Blot (WB)

FIGURE: 1 / 3

WAPL/WAPAL Antibody (16370-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 16370-1-AP) (WAPL; WAPAL antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Product Details

16370-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunocytochemistry (ICC/IF)

Assay-dependent

View 2 publications 2 publications

ChIP assay (ChIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

WAPL; WAPAL Fusion Protein Ag9280 (1-402 aa encoded by BC017393)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDLDRASLD LMIRLLELEQ DASSAKLLNE KDMNKIKEKI RRLCETVHNK HLDLENITTG HLAMETLLSL TSKRAGDWFK EELRLLGGLD HIVDKVKECV DHLSRDEDEE KLVASLWGAE RCLRVLESVT VHNPENQSYL IAYKDSQLIV SSAKALQHCE ELIQQYNRAE DSICLADSKP LPHQNVTNHV GKAVEDCMRA IIGVLLNLTN DNEWGSTKTG EQDGLIGTAL NCVLQVPKYL PQEQRFDIRV LLFLERERAA QLAESKTDEL IKDAPTTQHD KSGEWQETSG EIQWVSTEKT DGTEEKHKKE EEDEELDLNK ALQHAGKHME DCIVASYTAL LLGCLCQESP INVTTVREYL PEGDFSIMTE MLKKFLSFMN LTCAVGTTGQ KSISRVIEYL EHC (1-402 aa encoded by BC017393)

Target Information

Transcriptional repressor which may play a role in development of the central nervous system (CNS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Rearrangement of T Cell genome architecture regulates GVHD.

iScience

Sun Y,Dotson GA,Muir LA,Ronquist S,Oravecz-Wilson K,Peltier D,Seike K,Li L,Meixner W,Rajapakse I,Reddy P

Fri Sep 16 00:00:00 EDT 2022

CTCF and cohesin promote focal detachment of DNA from the nuclear lamina.

Genome biology

van Schaik T,Liu NQ,Manzo SG,Peric-Hupkes D,de Wit E,van Steensel B

Thu Sep 01 00:00:00 EDT 2022

RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis.

Science advances

Zhang S,Übelmesser N,Josipovic N,Forte G,Slotman JA,Chiang M,Gothe HJ,Gusmao EG,Becker C,Altmüller J,Houtsmuller AB,Roukos V,Wendt KS,Marenduzzo D,Papantonis A

Fri Oct 22 00:00:00 EDT 2021

WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.

Nature genetics

Liu NQ,Maresca M,van den Brand T,Braccioli L,Schijns MMGA,Teunissen H,Bruneau BG,Nora EP,de Wit E

Fri Jan 01 00:00:00 EST 2021

WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.

Nature genetics

Liu NQ,Maresca M,van den Brand T,Braccioli L,Schijns MMGA,Teunissen H,Bruneau BG,Nora EP,de Wit E

Fri Jan 01 00:00:00 EST 2021

WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.

Nature genetics

Liu NQ,Maresca M,van den Brand T,Braccioli L,Schijns MMGA,Teunissen H,Bruneau BG,Nora EP,de Wit E

Fri Jan 01 00:00:00 EST 2021

WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.

Nature genetics

Liu NQ,Maresca M,van den Brand T,Braccioli L,Schijns MMGA,Teunissen H,Bruneau BG,Nora EP,de Wit E

Fri Jan 01 00:00:00 EST 2021

WAPL orchestrates porcine oocyte meiotic progression via control of spindle assembly checkpoint activity.

Reproductive biology and endocrinology : RB&E

Zhou C,Miao Y,Zhang X,Xiong B

Mon Apr 19 00:00:00 EDT 2021

WAPL orchestrates porcine oocyte meiotic progression via control of spindle assembly checkpoint activity.

Reproductive biology and endocrinology : RB&E

Zhou C,Miao Y,Zhang X,Xiong B

Mon Apr 19 00:00:00 EDT 2021

Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.

Cell reports

Brieño-Enríquez MA,Moak SL,Toledo M,Filter JJ,Gray S,Barbero JL,Cohen PE,Holloway JK

Tue Oct 18 00:00:00 EDT 2016

Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.

Cell reports

Brieño-Enríquez MA,Moak SL,Toledo M,Filter JJ,Gray S,Barbero JL,Cohen PE,Holloway JK

Tue Oct 18 00:00:00 EDT 2016

Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.

Cell reports

Brieño-Enríquez MA,Moak SL,Toledo M,Filter JJ,Gray S,Barbero JL,Cohen PE,Holloway JK

Tue Oct 18 00:00:00 EDT 2016

Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.

Cell reports

Brieño-Enríquez MA,Moak SL,Toledo M,Filter JJ,Gray S,Barbero JL,Cohen PE,Holloway JK

Tue Oct 18 00:00:00 EDT 2016

Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.

Current biology : CB

Minamino M,Ishibashi M,Nakato R,Akiyama K,Tanaka H,Kato Y,Negishi L,Hirota T,Sutani T,Bando M,Shirahige K

Mon Jun 29 00:00:00 EDT 2015

Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.

Current biology : CB

Minamino M,Ishibashi M,Nakato R,Akiyama K,Tanaka H,Kato Y,Negishi L,Hirota T,Sutani T,Bando M,Shirahige K

Mon Jun 29 00:00:00 EDT 2015

Allogeneic T cell responses are regulated by a specific miRNA-mRNA network.

The Journal of clinical investigation

Sun Y,Tawara I,Zhao M,Qin ZS,Toubai T,Mathewson N,Tamaki H,Nieves E,Chinnaiyan AM,Reddy P

Fri Nov 01 00:00:00 EDT 2013

Allogeneic T cell responses are regulated by a specific miRNA-mRNA network.

The Journal of clinical investigation

Sun Y,Tawara I,Zhao M,Qin ZS,Toubai T,Mathewson N,Tamaki H,Nieves E,Chinnaiyan AM,Reddy P

Fri Nov 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: DIF-2; Dioxin-inducible factor 2; friend of EBNA2; friend of EBNA2 (Epstein-Barr virus nuclear protein 2); Friend of EBNA2 protein; WAPL cohesin release factor; Wings apart-like protein homolog

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Gene Aliases: A530089A20Rik; BC037674; DIF-2; FOE; KIAA0261; WAPAL; WAPL

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UniProt ID: (Human) Q7Z5K2, (Mouse) Q65Z40

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Entrez Gene ID: (Human) 23063, (Mouse) 218914

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Function(s)

protein binding molecular_function

Process(es)

sister chromatid cohesion mitotic sister chromatid cohesion negative regulation of DNA replication response to toxic substance viral process negative regulation of chromatin binding meiotic chromosome segregation negative regulation of sister chromatid cohesion positive regulation of fibroblast proliferation cell division regulation of chromosome condensation protein localization to chromatin regulation of cohesin loading cell cycle mitotic nuclear division regulation of chromosome segregation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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WAPL/WAPAL Polyclonal Antibody

WAPL/WAPAL Antibody (16370-1-AP) in WB

Product Details

16370-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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