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WASP Antibody (PA5-72617) in IHC (P)
Immunohistochemistry analysis of WASP in formalin fixed and paraffin embedded tonsil. Samples were incubated with WASP polyclonal antibody (Product # PA5-72617) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-72617
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 116-144 amino acids from the Central region of human WAS
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718471
Target Information
The Wiskott-Aldrich syndrome family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin nucleation-promoting factor WAS; eczema-thrombocytopenia; thrombocytopenia 1 (X-linked); WASp; Wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome protein homolog
Gene Aliases: IMD2; SCNX; THC; THC1; U42471; WAS; WASP; WASPA
UniProt ID: (Human) P42768, (Mouse) P70315
Entrez Gene ID: (Human) 7454, (Mouse) 22376
regulation of T cell antigen processing and presentation
protein complex assembly
defense response
immune response
blood coagulation
actin polymerization or depolymerization
epidermis development
endosomal transport
actin filament polymerization
actin filament-based movement
Fc-gamma receptor signaling pathway involved in phagocytosis
T cell activation
regulation of catalytic activity
T cell receptor signaling pathway
negative regulation of cell motility
positive regulation of Arp2/3 complex-mediated actin nucleation
actin filament organization
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