Invitrogen

WDR5 Monoclonal Antibody (7B11)

FIGURE: 1 / 1

WDR5 Antibody (MA5-15664) in WB

Western blot analysis of WDR5 using WDR5 monoclonal antibody (Product # MA5-15664) in HeLa (1) cell lysate.

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Product Details

MA5-15664

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

View 4 publications 4 publications

ELISA (ELISA)

1:10,000

Product Specifications

Species Reactivity

Human

Published species

Human, Pig

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

7B11

Immunogen

Purified recombinant fragment of human WDR5 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_10977947

Product Specific Information

MA5-15664 targets WDR5 in indirect ELISA, WB applications and shows reactivity with Human samples.

The MA5-15664 immunogen is purified recombinant fragment of human WDR5 expressed in E. Coli.

MA5-15664 detects WDR5 which has a predicted molecular weight of approximately 36.6kDa.

Target Information

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Reappraisal of hMLH1 promoter methylation and protein expression status in the serrated neoplasia pathway.

Histopathology

Lee EJ,Chun SM,Kim MJ,Jang SJ,Kim do S,Lee DH,Youk EG

MA515664 was used in immunohistochemistry - paraffin section to examine the methylation and inactivation of hMLH1 in the progression of sessile serrated lesions

Mon Aug 01 00:00:00 EDT 2016

CD109 Mediates Cell Survival in Hepatocellular Carcinoma Cells.

Digestive diseases and sciences

Zong G,Xu Z,Zhang S,Shen Y,Qiu H,Zhu G,He S,Tao T,Chen X

MA515664 was used in immunohistochemistry - paraffin section to investigate the molecular mechanisms that contribute to hepatocellular carcinoma

Mon Aug 01 00:00:00 EDT 2016

Low expression of PIDD is associated with cell proliferation and apoptosis in hepatocellular carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Shi W,Huang W,Chen Y,Zhang S,Xu P,Gu X,Fan H,Xu J,Chen Y,Ni R,Lu C,Zhang X

MA515664 was used in immunohistochemistry - paraffin section to determine the role of p53-induced death domain protein in hepatocellular carcinoma development

Mon Aug 01 00:00:00 EDT 2016

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.

PloS one

Bähr A,Käser T,Kemter E,Gerner W,Kurome M,Baars W,Herbach N,Witter K,Wünsch A,Talker SC,Kessler B,Nagashima H,Saalmüller A,Schwinzer R,Wolf E,Klymiuk N

MA515664 was used in immunohistochemistry - paraffin section to generate and characterize the immune system of CAG-LEA29Y transgenic pigs

Mon Jul 10 00:00:00 EDT 2017

Clonal X-chromosome inactivation suggests that splenic cord capillary hemangioma is a true neoplasm and not a subtype of splenic hamartoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Chiu A,Czader M,Cheng L,Hasserjian RP,Wang M,Bhagavathi S,Hyjek EM,Al-Ahmadie H,Knowles DM,Orazi A

MA5-15664 was used in Immunohistochemistry to show that in spite of considerable morphologic heterogeneity and overlapping features, classical hamartoma and cord capillary hemangioma and myoid angioendothelioma are different in terms of their vascular and stromal composition.

Sat Jan 01 00:00:00 EST 2011

Bioinformatics

Protein Aliases: BMP2-induced 3-kb gene protein; cilia and flagella associated protein 89; SWD3, Set1c WD40 repeat protein, homolog; WD repeat-containing protein 5

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Gene Aliases: BIG-3; BIG3; CFAP89; SWD3; WDR5

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UniProt ID: (Human) P61964

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Entrez Gene ID: (Human) 11091

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Function(s)

protein binding histone-lysine N-methyltransferase activity methylated histone binding histone methyltransferase activity (H3-K4 specific) histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K16 specific)

Process(es)

skeletal system development transcription, DNA-templated neuron projection development positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter histone H3 acetylation histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation histone H3-K4 methylation

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WDR5 Monoclonal Antibody (7B11)

WDR5 Antibody (MA5-15664) in WB

Product Details

MA5-15664

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

ELISA (ELISA)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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