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XDH Antibody (PA5-88946) in WB
Western blot analysis of XDH in extracts of various cell lines. Samples were incubated with XDH Polyclonal antibody (Product # PA5-88946) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-88946
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 985-1084 of human Xanthine Oxidase (XDH) (NP_0003702)
Conjugate
Form
Liquid
Concentration
1.63 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805243
Product Specific Information
Positive Samples: Mouse liver; Cellular Location: Cytoplasm, Peroxisome
Immunogen sequence: ETSTNTVPNT SPTAASVSA
Target Information
XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; xdh antibody; xdha antibody; xor antibody
Gene Aliases: XDH; XDHA; XO; XOR; Xox-1; Xox1
UniProt ID: (Human) P47989, (Rat) P22985, (Mouse) Q00519
Entrez Gene ID: (Human) 7498, (Rat) 497811, (Mouse) 22436
xanthine dehydrogenase activity
xanthine oxidase activity
iron ion binding
electron carrier activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors
protein homodimerization activity
molybdopterin cofactor binding
flavin adenine dinucleotide binding
2 iron, 2 sulfur cluster binding
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity
catalytic activity
protein binding
molybdenum ion binding
metal ion binding
iron-sulfur cluster binding
oxidoreductase
metabolite interconversion enzyme
negative regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
purine nucleotide catabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
lactation
xanthine catabolic process
negative regulation of gene expression
negative regulation of endothelial cell differentiation
negative regulation of protein kinase B signaling
oxidation-reduction process
positive regulation of p38MAPK cascade
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of reactive oxygen species metabolic process
negative regulation of vasculogenesis
response to aluminum ion
regulation of epithelial cell differentiation
bone resorption
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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