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Product Details
A301-993A-T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Between 700 and 750
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
ZAK is a leucine zipper-containing mitogen-activated protein related to the MLKs in both sequence and function. Like the MLKs and other MAP3Ks, ZAK activates MAP2Ks. ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif. This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HCCS-4; Human cervical cancer suppressor gene 4 protein; Leucine zipper- and sterile alpha motif-containing kinase; Mitogen-activated protein kinase kinase kinase 20; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase 7; mixed lineage kinase with a leucine zipper and a sterile alpha motif; Mixed lineage kinase-related kinase; mixed lineage kinase-related kinase MRK-beta; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; Sterile alpha motif- and leucine zipper-containing kinase AZK
Gene Aliases: AZK; HCCS4; MAP3K20; MLK7; mlklak; MLT; MLTK; MRK; pk; SFMMP; ZAK
UniProt ID: (Human) Q9NYL2
Entrez Gene ID: (Human) 51776
cell cycle checkpoint
DNA damage checkpoint
activation of MAPKK activity
protein phosphorylation
response to stress
cytoskeleton organization
cell cycle arrest
activation of JUN kinase activity
cell death
cell proliferation
response to radiation
cell differentiation
intracellular signal transduction
embryonic digit morphogenesis
positive regulation of apoptotic process
limb development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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