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ZC3HAV1 Antibody (PA5-106389) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded ZC3HAV1 in human liver tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with ZC3HAV1 polyclonal antibody (Product # PA5-106389) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-106389
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ZC3HAV1(Accession Q7Z2W4), corresponding to amino acid residues A288-D338.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2854063
Product Specific Information
Antibody detects endogenous levels of total ZC3HAV1.
Target Information
The zinc finger antiviral protein (ZC3HAV1) is a CCCH type zinc finger protein that induces an innate immunity to infections by retrovirus by preventing the accumulation of viral RNAs in the cytoplasm and recruits the RNA processing exosome to degrade target RNAs, thereby inhibiting virus replication. ZC3HAV1 is localized in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. ZAP is a direct target gene of IRF3 action in cellular antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; CCCH-type zinc finger antiviral protein (Zap); Inactive Poly [ADP-ribose] polymerase 13; PARP13; rZAP; ZAP; Zinc finger antiviral protein; Zinc finger CCCH domain-containing protein 2; Zinc finger CCCH-type antiviral protein 1; zinc finger CCCH-type, antiviral 1
Gene Aliases: 1200014N16Rik; 2900058M19Rik; 9130009D18Rik; 9830115L13Rik; ARTD13; D6Bwg1452e; FLB6421; PARP13; PRO1677; ZAP; ZC3H2; ZC3HAV1; ZC3HDC2
UniProt ID: (Human) Q7Z2W4, (Mouse) Q3UPF5
Entrez Gene ID: (Human) 56829, (Rat) 252832, (Mouse) 78781
response to virus
positive regulation of type I interferon production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
suppression by virus of host molecular function
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of viral genome replication
innate immune response
regulation of defense response to virus by host
defense response to virus
positive regulation of mRNA catabolic process
cellular response to exogenous dsRNA
positive regulation of RIG-I signaling pathway
immune system process
positive regulation of ATPase activity
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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