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ZPR1 Antibody (MA5-55625) in WB
Western blot analysis of ZPR1 in various protein samples (Lane 1: 15 µg of Jurkat lysate, Lane 2: 15 µg of rat liver tissue lysate, Lane 3: 15 µg of mouse liver tissue lysate). Sample was run on 6-18% SDS-PAGE under reducing conditions, blotted onto nitrocellulose membrane, followed by peroxidase conjugated rabbit anti-mouse IgG (Light chain specific) was used as the secondary antibody. ZPR1 band was visualized using ECL Western Blotting Substrate. Incubation with primary ZPR1 monoclonal antibody (Product # MA5-55625) at a dilution of 1 µg... View More
Product Details
MA5-55625
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K1E008_6E12
Immunogen
Recombinant human ZPR1 (immunogen range is 101-430).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
Sequence of this protein is as follows: VRYTLSVRAL EDMNREVVKT DSAATRIPEL DFEIPAFSQK GALTTVEGLI TRAISGLEQD QPARRANKDA TAERIDEFIV KLKELKQVAS PFTLIIDDPS GNSFVENPHA PQKDDALVIT HYNRTRQQEE MLGLQEEAPA EKPEEEDLRN EVLQFSTNCP ECNAPAQTNM KLVQIPHFKE VIIMATNCEN CGHRTNEVKS GGAVEPLGTR ITLHITDASD MTRDLLKSET CSVEIPELEF ELGMAVLGGK FTTLEGLLKD IRELVTKNPF TLGDSSNPGQ TERLQEFSQK MDQIIEGNMK AHFIMDDPAG NSYLQNVYAP EDDPEMKVER
Target Information
The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Zinc finger protein 259; Zinc finger protein ZPR1
Gene Aliases: AI303781; RGD1562173; Zfp259; ZNF259; ZPR1
UniProt ID: (Human) O75312, (Mouse) Q62384
Entrez Gene ID: (Human) 8882, (Rat) 500989, (Mouse) 22687
microtubule cytoskeleton organization
inner cell mass cell proliferation
trophectodermal cell proliferation
mRNA processing
multicellular organism development
RNA splicing
positive regulation of gene expression
spinal cord development
cell differentiation
Cajal body organization
regulation of myelination
positive regulation of RNA splicing
DNA endoreduplication
positive regulation of protein import into nucleus
positive regulation of growth
axon development
cellular response to epidermal growth factor stimulus
positive regulation of transcription involved in G1/S transition of mitotic cell cycle
apoptotic process involved in development
pre-mRNA catabolic process
negative regulation of motor neuron apoptotic process
signal transduction
cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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