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Product Details
PA5-117766
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived Human alpha Actinin 4/ACTN4 fragment
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2902377
Target Information
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actinin-Alpha-4; Alpha-actinin-4; focal segmental glomerulosclerosis 1; Non-muscle alpha-actinin 4
Gene Aliases: ACTININ-4; ACTN4; FSGS; FSGS1
UniProt ID: (Human) O43707
Entrez Gene ID: (Human) 81
RNA polymerase II regulatory region sequence-specific DNA binding
nucleoside binding
actin binding
integrin binding
calcium ion binding
protein binding
ligand-dependent nuclear receptor transcription coactivator activity
chromatin DNA binding
nuclear hormone receptor binding
protein homodimerization activity
retinoic acid receptor binding
ion channel binding
poly(A) RNA binding
protein N-terminus binding
actin filament binding
response to hypoxia
platelet degranulation
protein transport
vesicle transport along actin filament
positive regulation of cell migration
positive regulation of sodium:proton antiporter activity
peroxisome proliferator activated receptor signaling pathway
regulation of apoptotic process
retinoic acid receptor signaling pathway
positive regulation of pinocytosis
actin filament bundle assembly
negative regulation of cellular component movement
positive regulation of cellular component movement
bicellular tight junction assembly
negative regulation of substrate adhesion-dependent cell spreading
positive regulation of NIK/NF-kappaB signaling
protein localization to bicellular tight junction
regulation of nucleic acid-templated transcription
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