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Product Details
10546-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
alpha-SNAP Fusion Protein Ag0836 (1-295 aa encoded by BC007432)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes a 33 kDa protein in SDS page.
Immunogen sequence: MDNSGKEAE AMALLAEAER KVKNSQSFFS GLFGGSSKIE EACEIYARAA NMFKMAKNWS AAGNAFCQAA QLHLQLQSKH DAATCFVDAG NAFKKADPQE AINCLMRAIE IYTDMGRFTI AAKHHISIAE IYETELVDIE KAIAHYEQSA DYYKGEESNS SANKCLLKVA GYAALLEQYQ KAIDIYEQVG TNAMDSPLLK YSAKDYFFKA ALCHFCIDML NAKLAVQKYE ELFPAFSDSR ECKLMKKLLE AHEEQNVDSY TESVKEYDSI SRLDQWLTTM LLRIKKTIQG DEEDLR (1-295 aa encoded by B C007432)
Target Information
SNAPs (soluble NSF attachment proteins), acting in concert with SNAREs (SNAP receptors) and the N-ethylmaleimide-sensitive fusion protein (NSF) are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-to-endosome fusion and transcytotic vesicles-to-plasma membrane transport. Vesicle-to-target membrane docking (initial contact) occurs when the vesicle SNARE binds to its cognate target membrane SNARE. a-SNAP (or b-SNAP in brain) then binds to this docking complex and mediates the binding of NSF and thus the formation of a 20S fusion particle. It is thought that, once NSF is bound, ATP hydrolysis by NSF initiates the fusion process.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha snap; alpha soluble NSF attachment protein; alpha-SNAP; Alpha-soluble NSF attachment protein; hydrocephaly with hop gait; N-ethylmaleimide sensitive fusion protein attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein, alpha; SNAP-alpha
Gene Aliases: 1500039N14Rik; a-SNAP; alpha-SNAP; AW209189; hyh; NAPA; RA81; Snap; SNAPA; SNARE
UniProt ID: (Human) P54920, (Rat) P54921, (Mouse) Q9DB05
Entrez Gene ID: (Human) 8775, (Rat) 140673, (Mouse) 108124
intracellular protein transport
ER to Golgi vesicle-mediated transport
retrograde vesicle-mediated transport, Golgi to ER
intra-Golgi vesicle-mediated transport
brain development
regulation of synaptic vesicle priming
neuron differentiation
synaptic transmission, glutamatergic
SNARE complex disassembly
apical protein localization
COPII vesicle coating
membrane fusion
transport
protein transport
vesicle-mediated transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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