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Invitrogen
beta Dystroglycan Monoclonal Antibody (GT835)
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 8
beta Dystroglycan Antibody (MA5-35931) in ICC/IF
Immunofluorescent analysis of beta Dystroglycan in HeLa cells; (Green: DAG1/beta Dystroglycan stain). Sample was treated with 4% paraformaldehyde, incubated with monoclonal antibody (Product # MA5-35931) at a dilution of 1:100, followed by DAPI (blue).
Product Details
MA5-35931
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
GT835
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human DAG1/beta Dystroglycan. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2866548
Target Information
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-dystroglycan; beta-dystroglycan; Dystroglycan; Dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1
Gene Aliases: 156DAG; A3a; AGRNR; D9Wsu13e; DAG; DAG1; DG; Dp427; Dp71; MDDGA9; MDDGC7; MDDGC9
UniProt ID: (Human) Q14118, (Mouse) Q62165
Entrez Gene ID: (Human) 1605, (Mouse) 13138
morphogenesis of an epithelial sheet
protein O-linked glycosylation
membrane protein ectodomain proteolysis
NLS-bearing protein import into nucleus
cytoskeletal anchoring at plasma membrane
regulation of gastrulation
regulation of epithelial to mesenchymal transition
calcium-dependent cell-matrix adhesion
regulation of embryonic cell shape
modulation by virus of host morphology or physiology
nerve maturation
myelination in peripheral nervous system
extracellular matrix organization
negative regulation of cell migration
microtubule anchoring
negative regulation of MAPK cascade
response to peptide hormone
viral entry into host cell
negative regulation of protein kinase B signaling
epithelial tube branching involved in lung morphogenesis
branching involved in salivary gland morphogenesis
commissural neuron axon guidance
basement membrane organization
positive regulation of basement membrane assembly involved in embryonic body morphogenesis
Schwann cell development
viral process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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