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Invitrogen
p38 MAPK gamma Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
p38 MAPK gamma Antibody (PA5-80792) in WB
Western blot was performed using Anti-p38 MAPK gamma Polyclonal Antibody (Product # PA5-80792) and a 45kDa band corresponding to Mitogen-activated protein kinase 12 was observed across all the tested cell lines and tissues except MCF7, MOLT-4 and Mouse Thymus, and was upregulated upon differentiation of iPSC to cardiomyocytes. Whole cell extracts (30 µg lysate) of C2C12 (Lane 1), MDA-MB-231 (Lane 2), MCF7 (Lane 3), iPSC (Lane 4), iPSC (differentiated to cardiomyocytes) (Lane 5), HeLa (Lane 6), MOLT-4 (Lane 7), Mouse Thymus (Lane 8), Mouse ... View More
Product Details
PA5-80792
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human ERK3/MAPK12/P38-gamma Protein (Met1-Leu367)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2788068
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human ERK3/MAPK12/P38-gamma.
Target Information
MAPK12 (p38 gamma) is a serine/threonine kinase involved in many different cellular processes. It is activated during hypoxia and gamma-irradiation-induced G(2) arrest. Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. MAPK12 functions as a signal transducer during differentiation of myoblasts to myotubes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERK-6; ERK5; Extracellular signal-regulated kinase 6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; mitogen activated protein kinase 12; Mitogen-activated protein kinase 12; mitogen-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; OTTHUMP00000196671; SAP kinase-3; stress activated protein kinase 3; Stress-activated protein kinase 3
Gene Aliases: AW123708; ERK-6; ERK3; ERK6; MAPK 12; MAPK12; P38GAMMA; PRKM12; SAPK-3; SAPK3
UniProt ID: (Human) P53778, (Rat) Q63538, (Mouse) O08911
Entrez Gene ID: (Human) 6300, (Rat) 60352, (Mouse) 29857
magnesium ion binding
protein serine/threonine kinase activity
MAP kinase activity
protein binding
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
MAPK cascade
transcription, DNA-templated
regulation of transcription, DNA-templated
DNA damage induced protein phosphorylation
cell cycle arrest
signal transduction
muscle organ development
positive regulation of peptidase activity
peptidyl-serine phosphorylation
myoblast differentiation
vascular endothelial growth factor receptor signaling pathway
positive regulation of muscle cell differentiation
protein phosphorylation
negative regulation of cell cycle
cell cycle
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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