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Invitrogen
p38 MAPK gamma Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 3
p38 MAPK gamma Antibody (PA5-88940) in WB
Western blot was performed using Anti-p38 MAPK gamma Polyclonal Antibody (Product # PA5-88940) and a 45kDa band corresponding to Mitogen-activated protein kinase 12 was observed across in all tested cell lines and tissues except MOLT-4 and Mouse Thymus, and was upregulated upon differentiation of C2C12 to myoblast and iPSC to cardiomyocytes. Whole cell extracts (30 µg lysate) of C2C12 (Lane 1), C2C12 (differentiated to Myoblast) (Lane 2), MDA-MB-231 (Lane 3), MCF7 (Lane 4), iPSC (Lane 5), iPSC (differentiated to Cardiomyocytes) (Lane 6), H... View More
Product Details
PA5-88940
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 248-367 of human MAPK12 (NP_0029602)
Conjugate
Form
Liquid
Concentration
0.68 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805238
Product Specific Information
Immunogen sequence: EFVQRLQSDE AKNYMKGLPE LEKKDFASIL TNASPLAVNL LEKMLVLDAE QRVTAGEALA HPYFESLHDT EDEPQVQKYD DSFDDVDRTL DEWKRVTYKE VLSFKPPRQL GARVSKETPL; Positive Samples: HeLa, K-562, PC-12, 22Rv1, Mouse lung, Mouse testis; Cellular Location: Cytoplasm, Mitochondrion, Nucleus
Target Information
MAPK12 (p38 gamma) is a serine/threonine kinase involved in many different cellular processes. It is activated during hypoxia and gamma-irradiation-induced G(2) arrest. Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. MAPK12 functions as a signal transducer during differentiation of myoblasts to myotubes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERK-6; ERK5; Extracellular signal-regulated kinase 6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; mitogen activated protein kinase 12; Mitogen-activated protein kinase 12; mitogen-activated protein kinase 3; Mitogen-activated protein kinase p38 gamma; OTTHUMP00000196671; SAP kinase-3; stress activated protein kinase 3; Stress-activated protein kinase 3
Gene Aliases: AW123708; ERK-6; ERK3; ERK6; MAPK 12; MAPK12; P38GAMMA; PRKM12; SAPK-3; SAPK3
UniProt ID: (Human) P53778, (Rat) Q63538, (Mouse) O08911
Entrez Gene ID: (Human) 6300, (Rat) 60352, (Mouse) 29857
magnesium ion binding
protein serine/threonine kinase activity
MAP kinase activity
protein binding
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
MAPK cascade
transcription, DNA-templated
regulation of transcription, DNA-templated
DNA damage induced protein phosphorylation
cell cycle arrest
signal transduction
muscle organ development
positive regulation of peptidase activity
peptidyl-serine phosphorylation
myoblast differentiation
vascular endothelial growth factor receptor signaling pathway
positive regulation of muscle cell differentiation
protein phosphorylation
negative regulation of cell cycle
cell cycle
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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