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Product Details
RP-43073
Product Specifications
Species
Bovine
Molecular weight
55.1 kDa
Class
Native
Type
Protein
Conjugate
Form
Liquid
Concentration
6.0 mg/mL
Purification
purified
Storage buffer
50% water with 50% glycerol
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
RP-43073 contains native bovine Factor X protein.
RP-43073 may be used as a positive control in many immunological assays.
Target Information
F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coagulation factor X; Factor 10; Factor10; RP11-98F14.9; Stuart factor; unnamed protein product
Gene Aliases: F10
UniProt ID: (Bovine) P00743
Entrez Gene ID: (Bovine) 280787
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