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Product Details
PEP-0557
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human TEM4.
PEP-0557 can be used as a blocking peptide with polyclonal antibody PA5-20440.
Target Information
Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 164 kDa Rho-specific guanine-nucleotide exchange factor; p164-RhoGEF; Rho guanine nucleotide exchange factor (GEF) 17; Rho guanine nucleotide exchange factor 17; Rho-specific guanine-nucleotide exchange factor 164 kDa; Tumor endothelial marker 4
Gene Aliases: ARHGEF17; KIAA0337; p164-RhoGEF; P164RHOGEF; TEM4
UniProt ID: (Human) Q96PE2
Entrez Gene ID: (Human) 9828
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